Literature DB >> 641772

Drug absorption VIII: Kinetics of GI absorption of methotrexate.

V S Chungi, D W Bourne, L W Dittert.   

Abstract

The absorption of methotrexate from the lumen of the rat small intestine, in situ, was found to obey Michaelis--Menten kinetics. The values of Vmax and Km for the absorption process were 4.78 X 10(-7) M/min and 1.49 X 10(-5) M, respectively.

Entities:  

Mesh:

Substances:

Year:  1978        PMID: 641772     DOI: 10.1002/jps.2600670434

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN: 0022-3549            Impact factor:   3.534


  2 in total

Review 1.  Optimising low-dose methotrexate for rheumatoid arthritis-A review.

Authors:  Catherine J Lucas; Simon B Dimmitt; Jennifer H Martin
Journal:  Br J Clin Pharmacol       Date:  2019-08-09       Impact factor: 4.335

2.  Relative bioavailability of oral low dose methotrexate. A comparison of 2 different formulations.

Authors:  S D Fosså; K Tveit; O Börmer; A Moxnes; N P Jørgensen; H Orjaseter; D T Kristoffersen
Journal:  Eur J Clin Pharmacol       Date:  1988       Impact factor: 2.953

  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.