Literature DB >> 6417676

Inhibition by AA861 of prostaglandin E2 production by activated peritoneal macrophages of rat.

K Ohuchi, M Watanabe, J Taniguchi, S Tsurufuji, L Levine.   

Abstract

Prostaglandin E2 production by rat peritoneal activated macrophages was inhibited by AA861 which had been reported as a selective inhibitor of 5-lipoxygenase from guinea pig peritoneal leukocytes. At a dose of 3.06 microM, prostaglandin E2 production was decreased to 27% of control. No inhibition of the release of (3H)arachidonic acid from the prelabeled macrophages was observed at the dose.

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Year:  1983        PMID： 6417676     DOI： 10.1016/0262-1746(83)90081-1

Source DB:  PubMed          Journal:  Prostaglandins Leukot Med        ISSN： 0262-1746


  3 in total

1.  Elucidation of the molecular mechanism and the efficacy in vivo of a novel 1,4-benzoquinone that inhibits 5-lipoxygenase.

Authors:  A M Schaible; R Filosa; V Temml; V Krauth; M Matteis; A Peduto; F Bruno; S Luderer; F Roviezzo; A Di Mola; M de Rosa; B D'Agostino; C Weinigel; D Barz; A Koeberle; C Pergola; D Schuster; O Werz
Journal:  Br J Pharmacol       Date:  2014-05       Impact factor: 8.739

2.  Lectins modulate prostaglandin E2 production by rat peritoneal macrophages.

Authors:  K Ohuchi; M Watanabe; E Takahashi; S Tsurufuji; K Imanishi; I Suzuki; L Levine
Journal:  Agents Actions       Date:  1984-10

3.  Inhibitors of Human 5-Lipoxygenase Potently Interfere With Prostaglandin Transport.

Authors:  Astrid S Kahnt; Carlo Angioni; Tamara Göbel; Bettina Hofmann; Jessica Roos; Svenja D Steinbrink; Florian Rörsch; Dominique Thomas; Gerd Geisslinger; Kai Zacharowski; Sabine Grösch; Dieter Steinhilber; Thorsten J Maier
Journal:  Front Pharmacol       Date:  2022-01-21       Impact factor: 5.810
  3 in total

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