Literature DB >> 6416893

Cytosol Mg2+ modulates Ca2+ ionophore induced secretion from rabbit neutrophils.

F Di Virgilio, B D Gomperts.   

Abstract

The influence of extracellular Mg2+ on Ca2+ ionophore (A23187 and ionomycin) induced secretion and changes in the cytosol pH of rabbit neutrophils suspended in Ca2+-free buffer has been investigated. While extracellular Ca2+ is obligatory for ionomycin induced secretion, we have defined conditions under which A23187 can induce secretion in Ca2+-free media. The different behaviour of these two Ca2+ ionophores is discussed on the basis of their different counter cation specificities.

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Year:  1983        PMID： 6416893     DOI： 10.1016/0014-5793(83)80843-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  3 in total

1.  Novel P2X7 receptor antagonists ease the pain.

Authors:  B F King
Journal:  Br J Pharmacol       Date:  2007-04-30       Impact factor: 8.739

2.  Cyclic AMP inhibition of fMet-Leu-Phe-dependent metabolic responses in human neutrophils is not due to its effects on cytosolic Ca2+.

Authors:  P De Togni; G Cabrini; F Di Virgilio
Journal:  Biochem J       Date:  1984-12-01       Impact factor: 3.857

3.  Transmembrane sodium and potassium gradients modulate histamine secretion induced by ionophore A23187.

Authors:  M Amellal; C Bronner; Y Landry
Journal:  Br J Pharmacol       Date:  1985-08       Impact factor: 8.739
  3 in total

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