| Literature DB >> 6415725 |
D Luttinger, S K Burgess, C B Nemeroff, A J Prange.
Abstract
Previous studies have shown that the opioid antagonist naloxone does not alter neurotensin (NT)-induced antinociception. In the present studies, tolerance to morphine in mice significantly attenuated NT-induced antinociception, but not NT-induced hypothermia. In addition, centrally administered NT inhibited naloxone-precipitated jumping in morphine-dependent mice. These results indicate complex interactions between NT-induced antinociception and opioid systems.Entities:
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Year: 1983 PMID: 6415725 DOI: 10.1007/BF00439265
Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN: 0033-3158 Impact factor: 4.530