Literature DB >> 6415511

Comparison of valproic acid and phenytoin in newly diagnosed tonic-clonic seizures.

B J Wilder, R E Ramsay, J V Murphy, B J Karas, K Marquardt, E J Hammond.   

Abstract

Sixty-one newly diagnosed epileptic patients with generalized tonic-clonic, clonic, or tonic seizures were randomly allocated to treatment with valproate (VPA) and phenytoin (PHT). After 6 months, both drugs had been effective in preventing recurrence of seizures. Seventy-three percent of patients receiving VPA and 47% of patients receiving PHT had no recurrences. Side effects of either drug were mild. Laboratory abnormalities were similar for both drugs. Except for one PHT patient with toxic hepatitis, therapy was not discontinued.

Entities:  

Mesh：

Substances：

Year:  1983        PMID： 6415511     DOI： 10.1212/wnl.33.11.1474

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  15 in total

1.  Complex Partial Seizures in Adults.

Authors: 
Journal:  Curr Treat Options Neurol       Date:  1999-09       Impact factor: 3.598

Review 2.  Management of focal-onset seizures: an update on drug treatment.

Authors:  Svein I Johannessen; Elinor Ben-Menachem
Journal:  Drugs       Date:  2006       Impact factor: 9.546

Review 3.  Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.

Authors:  Sarah J Nevitt; Maria Sudell; Jennifer Weston; Catrin Tudur Smith; Anthony G Marson
Journal:  Cochrane Database Syst Rev       Date:  2017-06-29

4.  The comparative efficacy of antiepileptic drugs for partial and tonic-clonic seizures.

Authors:  D Chadwick; D M Turnbull
Journal:  J Neurol Neurosurg Psychiatry       Date:  1985-11       Impact factor: 10.154

Review 5.  Phenytoin versus valproate monotherapy for partial onset seizures and generalised onset tonic-clonic seizures: an individual participant data review.

Authors:  Sarah J Nolan; Anthony G Marson; Jennifer Weston; Catrin Tudur Smith
Journal:  Cochrane Database Syst Rev       Date:  2016-04-28

Review 6.  Drug treatment of epilepsy. Outlines, criticism and perspectives.

Authors:  E Beghi; R Di Mascio; G Tognoni
Journal:  Drugs       Date:  1986-03       Impact factor: 9.546

7.  Phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed adult epilepsy: a randomised comparative monotherapy trial.

Authors:  A J Heller; P Chesterman; R D Elwes; P Crawford; D Chadwick; A L Johnson; E H Reynolds
Journal:  J Neurol Neurosurg Psychiatry       Date:  1995-01       Impact factor: 10.154

8.  The relationship between treatment with valproate, lamotrigine, and topiramate and the prognosis of the idiopathic generalised epilepsies.

Authors:  A Nicolson; R E Appleton; D W Chadwick; D F Smith
Journal:  J Neurol Neurosurg Psychiatry       Date:  2004-01       Impact factor: 10.154

9.  Single-dose tolerance and pharmacokinetics of 2-n-propyl-2(E)-pentenoate (delta 2(E)-valproate) in healthy male volunteers.

Authors:  R H Düsing
Journal:  Pharm Weekbl Sci       Date:  1992-06-19

10.  Comparative efficacy of antiepileptic drugs for patients with generalized epileptic seizures: systematic review and network meta-analyses.

Authors:  Marília Silveira de Almeida Campos; Lorena Rocha Ayres; Manuela Roque Siane Morelo; Fabiana Angelo Marques Carizio; Leonardo Régis Leira Pereira
Journal:  Int J Clin Pharm       Date:  2018-05-09
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.