Literature DB >> 6414824

Anxiogenic aspects of diazepam withdrawal can be detected in animals.

M Emmett-Oglesby, D Spencer, M Lewis, F Elmesallamy, H Lal.   

Abstract

Animals can be trained to discriminate the presence of pentylenetetrazol, and this discrimination has previously been proposed as an animal bioassay for anxiogenicity. In rats made dependent on diazepam, pentylenetetrazol-like stimuli occurred during spontaneous or precipitated (with RO 15-1788) withdrawal; these stimuli were blocked by pentobarbital. These results demonstrate that the pentylenetetrazol-based animal model of anxiety can be used to objectively quantify a subjective aspect of benzodiazepine dependence/withdrawal.

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Year:  1983        PMID： 6414824     DOI： 10.1016/0014-2999(83)90117-6

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  8 in total

1.  Opioid modulation of the discriminative stimulus produced by pentylenetetrazol.

Authors:  M W Emmett-Oglesby; A Herz
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

Review 2.  Trends in drug discrimination research analysed with a cross-indexed bibliography, 1982-1983.

Authors:  I P Stolerman; P J Shine
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

Review 3.  Aggression, anxiety and vocalizations in animals: GABAA and 5-HT anxiolytics.

Authors:  K A Miczek; E M Weerts; J A Vivian; H M Barros
Journal:  Psychopharmacology (Berl)       Date:  1995-09       Impact factor: 4.530

4.  Defeat engenders pentylenetetrazole-appropriate responding in rats: antagonism by midazolam.

Authors:  J A Vivian; E M Weerts; K A Miczek
Journal:  Psychopharmacology (Berl)       Date:  1994-12       Impact factor: 4.530

5.  Time dependent pentylenetetrazol-like cues subsequent to diazepam administration.

Authors:  R J Barrett; R L Smith
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

Review 6.  Animal models of drug withdrawal symptoms.

Authors:  M W Emmett-Oglesby; D A Mathis; R T Moon; H Lal
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

7.  A theory of benzodiazepine dependence that can explain whether flumazenil will enhance or reverse the phenomena.

Authors:  S E File; P K Hitchcott
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

8.  Changes in noradrenaline plasma levels and behavioural responses induced by benzodiazepine agonists with the benzodiazepine antagonist Ro 15-1788.

Authors:  T Duka; M Ackenheil; J Noderer; A Doenicke; R Dorow
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530
  8 in total

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