Literature DB >> 6413976

Inhibition of muscle differentiation by trypanosoma cruzi.

K S Rowin, H B Tanowitz, M Wittner, H T Nguyen, B Nadal-Ginard.   

Abstract

L6E9 rat myoblasts were infected in tissue culture with the myotropic Brazil strain of Trypanosoma cruzi. The effect of parasite infection on the ability of myoblasts to differentiate into myotubes was studied. Both morphological and biochemical differentiation were found to be profoundly affected by parasitic infection in a dose-related fashion. Evidence is presented to suggest that infected myoblasts can no longer differentiate. Differentiation, once underway, seemed unaffected by the parasitic infection; biochemical markers of differentiation remained intact.

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Year:  1983        PMID： 6413976      PMCID： PMC394303          DOI： 10.1073/pnas.80.20.6390

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  25 in total

1.  Immunopathologic and morphologic studies of skeletal muscle in Chagas' disease.

Authors:  R P Laguens; P M Cossio; C Diez; A Segal; C Vasquez; E Kreutzer; E Khoury; R M Arana
Journal:  Am J Pathol       Date:  1975-07       Impact factor: 4.307

2.  Is fusion a trigger for myoblast differentiation?

Authors:  D Delain; J P Wahrmann
Journal:  Exp Cell Res       Date:  1975-07       Impact factor: 3.905

3.  Temperature-sensitive expression of differentiation in transformed myoblasts.

Authors:  M Y Fiszman; P Fuchs
Journal:  Nature       Date:  1975-04-03       Impact factor: 49.962

4.  Viral transformation of rat myoblasts: effects on fusion and surface properties.

Authors:  R O Hynes; G S Martin; M Shearer; D R Critchley; C J Epstein
Journal:  Dev Biol       Date:  1976-01       Impact factor: 3.582

5.  Effect of oncogenic virus on muscle differentiation.

Authors:  H Holtzer; J Biehl; G Yeoh; R Meganathan; A Kaji
Journal:  Proc Natl Acad Sci U S A       Date:  1975-10       Impact factor: 11.205

6.  Trypanosoma cruzi: interaction with vertebrate cells in vitro. 1. Individual interactions at the cellular and subcellular levels.

Authors:  J A Dvorak; T P Hyde
Journal:  Exp Parasitol       Date:  1973-10       Impact factor: 2.011

7.  Chagasic cardiopathy. Demonstration of a serum gamma globulin factor which reacts with endocardium and vascular structures.

Authors:  P M Cossio; C Diez; A Szarfman; E Kreutzer; B Candiolo; R M Arana
Journal:  Circulation       Date:  1974-01       Impact factor: 29.690

8.  Studies of in vitro infection by Trypanosoma cruzi. I. Ultrastructural studies on the invasion of macrophages and L-cells.

Authors:  H Tanowitz; M Wittner; Y Kress; B Bloom
Journal:  Am J Trop Med Hyg       Date:  1975-01       Impact factor: 2.345

9.  Effect of chagasic sera on the rat isolated atrial preparation: immunological, morphological and function aspects.

Authors:  L Sterin-Borda; P M Cossio; M F Gimeno; A L Gimeno; C Diez; R P Laguens; P C Meckert; R M Arana
Journal:  Cardiovasc Res       Date:  1976-11       Impact factor: 10.787

10.  The immunology of experimental Chagas' disease. IV. Production of lesions in rabbits similar to those of chronic Chagas' disease in man.

Authors:  A R Teixeira; M L Teixeira; C A Santos-Buch
Journal:  Am J Pathol       Date:  1975-07       Impact factor: 4.307
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  16 in total

1.  Transcriptomic signatures of alterations in a myoblast cell line infected with four distinct strains of Trypanosoma cruzi.

Authors:  Daniel Adesse; Dumitru A Iacobas; Sanda Iacobas; Luciana R Garzoni; Maria de Nazareth Meirelles; Herbert B Tanowitz; David C Spray
Journal:  Am J Trop Med Hyg       Date:  2010-05       Impact factor: 2.345

2.  Developmental expression of a Trypanosoma cruzi phosphoinositide-specific phospholipase C in amastigotes and stimulation of host phosphoinositide hydrolysis.

Authors:  Vicente de Paulo Martins; Melina Galizzi; Maria Laura Salto; Roberto Docampo; Silvia N J Moreno
Journal:  Infect Immun       Date:  2010-07-19       Impact factor: 3.441

3.  Trypanosoma cruzi infection induces proliferation of vascular smooth muscle cells.

Authors:  Ghada S Hassan; Shankar Mukherjee; Fnu Nagajyothi; Louis M Weiss; Stefka B Petkova; Cecilia J de Almeida; Huan Huang; Mahalia S Desruisseaux; Boumediene Bouzahzah; Richard G Pestell; Chris Albanese; George J Christ; Michael P Lisanti; Herbert B Tanowitz
Journal:  Infect Immun       Date:  2006-01       Impact factor: 3.441

4.  Curcumin treatment provides protection against Trypanosoma cruzi infection.

Authors:  Fnu Nagajyothi; Dazhi Zhao; Louis M Weiss; Herbert B Tanowitz
Journal:  Parasitol Res       Date:  2012-01-04       Impact factor: 2.289

5.  Inhibition of mammalian muscle differentiation by excretory secretory products of muscle larvae of Trichinella spiralis in vitro.

Authors:  Xue Bai; Xiuping Wu; Xuelin Wang; Xiaolei Liu; Yanxia Song; Fei Gao; Yajuan Miao; Lu Yu; Bin Tang; Xinrui Wang; Blaga Radu; Isabelle Vallee; Pascal Boireau; Feng Wang; Ying Zhao; Mingyuan Liu
Journal:  Parasitol Res       Date:  2011-12-27       Impact factor: 2.289

6.  Infection of endothelial cells with Trypanosoma cruzi activates NF-kappaB and induces vascular adhesion molecule expression.

Authors:  H Huang; T M Calderon; J W Berman; V L Braunstein; L M Weiss; M Wittner; H B Tanowitz
Journal:  Infect Immun       Date:  1999-10       Impact factor: 3.441

7.  The interaction of myotropic and macrophagotropic strains of Trypanosoma cruzi with myoblasts and fibers of skeletal muscle.

Authors:  T C Araújo Jorge; H S Barbosa; A L Moreira; W De Souza; M N Meirelles
Journal:  Z Parasitenkd       Date:  1986

8.  Trypanosoma cruzi infection activates extracellular signal-regulated kinase in cultured endothelial and smooth muscle cells.

Authors:  Shankar Mukherjee; Huan Huang; Stefka B Petkova; Chris Albanese; Richard G Pestell; Vicki L Braunstein; George J Christ; Murray Wittner; Michael P Lisanti; Joan W Berman; Louis M Weiss; Herbert B Tanowitz
Journal:  Infect Immun       Date:  2004-09       Impact factor: 3.441

9.  Trypanosoma cruzi infection of cultured adipocytes results in an inflammatory phenotype.

Authors:  Fnu Nagajyothi; Mahalia S Desruisseaux; Niranjan Thiruvur; Louis M Weiss; Vicki L Braunstein; Chris Albanese; Mauro M Teixeira; Cecilia J de Almeida; Michael P Lisanti; Philipp E Scherer; Herbert B Tanowitz
Journal:  Obesity (Silver Spring)       Date:  2008-09       Impact factor: 5.002

10.  Trypanosoma cruzi induces changes in cardiac connexin43 expression.

Authors:  Daniel Adesse; Luciana R Garzoni; Huan Huang; Herbert B Tanowitz; Maria de Nazareth Meirelles; David C Spray
Journal:  Microbes Infect       Date:  2007-10-02       Impact factor: 2.700
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