Literature DB >> 6413803

Metabolism of platelet-activating factor by blood platelets and plasma.

I Alam, J B Smith, M J Silver.   

Abstract

High performance liquid chromatography in combination with a radioactivity detector was used to study the metabolism of platelet-activating factor (1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by washed platelets, platelet-free plasma and platelet-rich plasma obtained from rabbits and humans. Degradation of platelet-activating factor to its 2-lyso derivative was observed in rabbit and human plasma. This degradation of platelet-activating factor in plasma was completely inhibited by diisopropylfluorophosphate and was partially inhibited by ethylenediamine tetraacetic acid. Washed platelets metabolized platelet-activating factor not only to the 2-lyso compound but also, by reacylation of this lyso intermediate, to an analogue of platelet-activating factor probably containing a long-chain acyl group at the sn-2 position. These transformations occurred, but to a lesser extent, in platelet-rich plasma.

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Year:  1983        PMID： 6413803     DOI： 10.1007/BF02535393

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  20 in total

1.  Structural analysis of purified platelet-activating factor by lipases.

Authors:  J Benveniste; J P Le Couedic; J Polonsky; M Tence
Journal:  Nature       Date:  1977-09-08       Impact factor: 49.962

2.  Platelet-activating factor, a new mediator of anaphylaxis and immune complex deposition from rabbit and human basophils.

Authors:  J Benveniste
Journal:  Nature       Date:  1974-06-07       Impact factor: 49.962

3.  Antihypertensive activity of an alkyl ether analog of phosphatidylcholine.

Authors:  M L Blank; F Snyder; L W Byers; B Brooks; E E Muirhead
Journal:  Biochem Biophys Res Commun       Date:  1979-10-29       Impact factor: 3.575

4.  Activities of enzymes that metabolize platelet-activating factor (1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine) in neutrophils and eosinophils from humans and the effect of a calcium ionophore.

Authors:  T C Lee; B Malone; S I Wasserman; V Fitzgerald; F Snyder
Journal:  Biochem Biophys Res Commun       Date:  1982-04-29       Impact factor: 3.575

5.  Platelet-activating factor. Evidence for 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine as the active component (a new class of lipid chemical mediators).

Authors:  C A Demopoulos; R N Pinckard; D J Hanahan
Journal:  J Biol Chem       Date:  1979-10-10       Impact factor: 5.157

6.  A specific acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a hypotensive and platelet-activating lipid).

Authors:  M L Blank; T Lee; V Fitzgerald; F Snyder
Journal:  J Biol Chem       Date:  1981-01-10       Impact factor: 5.157

7.  Cyclic adenosine 3',5'-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions.

Authors:  M Minkes; N Stanford; M M Chi; G J Roth; A Raz; P Needleman; P W Majerus
Journal:  J Clin Invest       Date:  1977-03       Impact factor: 14.808

8.  Ether lipid content and fatty acid distribution in rabbit polymorphonuclear neutrophil phospholipids.

Authors:  H W Mueller; J T O'Flaherty; R L Wykle
Journal:  Lipids       Date:  1982-02       Impact factor: 1.880

9.  Glycerophospholipid synthesis: improved general method and new analogs containing photoactivable groups.

Authors:  C M Gupta; R Radhakrishnan; H G Khorana
Journal:  Proc Natl Acad Sci U S A       Date:  1977-10       Impact factor: 11.205

10.  Ether phospholipids in guinea pig polymorphonuclear leukocytes and macrophages. Occurrence of high levels of 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine.

Authors:  T Sugiura; Y Onuma; N Sekiguchi; K Waku
Journal:  Biochim Biophys Acta       Date:  1982-09-14
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  8 in total

1.  Characterization of serum platelet-activating factor (PAF) acetylhydrolase. Correlation between deficiency of serum PAF acetylhydrolase and respiratory symptoms in asthmatic children.

Authors:  M Miwa; T Miyake; T Yamanaka; J Sugatani; Y Suzuki; S Sakata; Y Araki; M Matsumoto
Journal:  J Clin Invest       Date:  1988-12       Impact factor: 14.808

2.  Occupancy of platelet receptors for platelet-activating factor in patients with septicemia.

Authors:  F Lopez Diez; M L Nieto; S Fernandez-Gallardo; M A Gijon; M Sanchez Crespo
Journal:  J Clin Invest       Date:  1989-05       Impact factor: 14.808

3.  The role of Ca2+ in regulating the catabolism of PAF-acether (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in rabbit platelets.

Authors:  L Touqui; A M Shaw; C Dumarey; C Jacquemin; B B Vargaftig
Journal:  Biochem J       Date:  1987-01-15       Impact factor: 3.857

4.  Human platelets stimulated by thrombin produce platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when the degrading enzyme acetyl hydrolase is blocked.

Authors:  L Touqui; M Hatmi; B B Vargaftig
Journal:  Biochem J       Date:  1985-08-01       Impact factor: 3.857

5.  Platelet activating factor as a mediator of equine cell locomotion.

Authors:  J Dawson; P Lees; A D Sedgwick
Journal:  Vet Res Commun       Date:  1988       Impact factor: 2.459

6.  Binding kinetics of PAF-acether (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) to intact human platelets.

Authors:  E Kloprogge; J W Akkerman
Journal:  Biochem J       Date:  1984-11-01       Impact factor: 3.857

7.  Hydrolysis and transesterification of platelet-activating factor by lecithin-cholesterol acyltransferase.

Authors:  M Liu; P V Subbaiah
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-21       Impact factor: 11.205

8.  Phospholipid biosynthesis in human platelets. The acylation of lyso-platelet-activating factor.

Authors:  M L McKean; M J Silver
Journal:  Biochem J       Date:  1985-02-01       Impact factor: 3.857
  8 in total

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