Literature DB >> 6413552

Defective platelet aggregation to the calcium ionophore A23187 in a patient with a lifelong bleeding disorder.

S J Machin, J P Keenan, B A McVerry.   

Abstract

A patient with a lifelong bleeding disorder is presented with a prolonged bleeding time and abnormal aggregation and secretion responses to arachidonic acid, thromboxane A2, PAF-acether and the divalent calcium ionophore A23187. Platelet alpha and dense granule contents and morphology appear normal. The proposed defect is due to an abnormality of a platelet intracellular calcium dependent process.

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Year:  1983        PMID： 6413552      PMCID： PMC498490          DOI： 10.1136/jcp.36.10.1140

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  16 in total

Review 1.  Cyclic nucleotides in platelet function.

Authors:  R J Haslam; M M Davidson; J E Fox; J A Lynham
Journal:  Thromb Haemost       Date:  1978-10-31       Impact factor: 5.249

2.  Platelet factor VIII-related antigen: studies in vivo after transfusion in patients with von Willebrand disease.

Authors:  Y Sultan; C Jeanneau; J Lamaziere; P Maisonneuve; J P Caen
Journal:  Blood       Date:  1978-04       Impact factor: 22.113

3.  Platelet antiheparin activity. Assay based on factor-Xa inactivation by heparin and antifactor Xa.

Authors:  P N Walsh; R Biggs; G Gagnatelli
Journal:  Br J Haematol       Date:  1974-03       Impact factor: 6.998

4.  Platelet-activating factor (PAF-acether) secretion from platelets: effect of aggregating agents.

Authors:  M Chignard; J P Le Couedic; B B Vargaftig; J Benveniste
Journal:  Br J Haematol       Date:  1980-11       Impact factor: 6.998

5.  Calcium-dependent proteins in platelets: response of calcium-activated protease in normal and thrombasthenic platelets to aggregating agents.

Authors:  G C White
Journal:  Biochim Biophys Acta       Date:  1980-08-01

6.  The effects of trifluoperazine, an inhibitor of calmodulin, on platelet function.

Authors:  G C White; S T Raynor
Journal:  Thromb Res       Date:  1980 Apr 1-15       Impact factor: 3.944

7.  Thrombocytopathy in preleukaemia: association with a defect of thromboxane A2 activity.

Authors:  N H Russell; J P Keenan; A J Bellingham
Journal:  Br J Haematol       Date:  1979-03       Impact factor: 6.998

8.  Impaired platelet response to thromboxane-A2 and defective calcium mobilization in a patient with a bleeding disorder.

Authors:  B Lages; C Malmsten; H J Weiss; B Samuelsson
Journal:  Blood       Date:  1981-03       Impact factor: 22.113

9.  Evidence that calcium regulates platelet function.

Authors:  T C Detwiler; I F Charo; R D Feinman
Journal:  Thromb Haemost       Date:  1978-10-31       Impact factor: 5.249

10.  Human platelet secretion and aggregation induced by calcium ionophores. Inhibition by PGE1 and dibutyryl cyclic AMP.

Authors:  M B Feinstein; C Fraser
Journal:  J Gen Physiol       Date:  1975-11       Impact factor: 4.086
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  1 in total

1.  Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder.

Authors:  T Hirata; A Kakizuka; F Ushikubi; I Fuse; M Okuma; S Narumiya
Journal:  J Clin Invest       Date:  1994-10       Impact factor: 14.808
  1 in total

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