Literature DB >> 6412158

The renal origin of sodium valproate-induced hyperammonemia in fasting humans.

J M Warter, C Brandt, C Marescaux, L Rumbach, G Micheletti, G Chabrier, J Krieger, M Imler.   

Abstract

Acute administration of 1,500 mg of sodium valproate or chronic administration of 30 mg/kg/24 hours induced a more than twofold increase of renal ammoniagenesis in fasting subjects. Hyperammonemia was moderate, as normal hepatic ammonia detoxification persisted. Renal uptake of glutamine increased simultaneously.

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Year:  1983        PMID: 6412158     DOI: 10.1212/wnl.33.9.1136

Source DB:  PubMed          Journal:  Neurology        ISSN: 0028-3878            Impact factor:   9.910


  11 in total

1.  Case files of the Children's Hospital of Michigan Regional Poison Control Center: the use of carnitine for the management of acute valproic acid toxicity.

Authors:  Abhishek Katiyar; Cynthia Aaron
Journal:  J Med Toxicol       Date:  2007-09

2.  Evidence of inherited urea cycle defect in a case of fatal valproate toxicity.

Authors:  M Hjelm; L V de Silva; J W Seakins; V G Oberholzer; C J Rolles
Journal:  Br Med J (Clin Res Ed)       Date:  1986-01-04

Review 3.  Roles of renal ammonia metabolism other than in acid-base homeostasis.

Authors:  I David Weiner
Journal:  Pediatr Nephrol       Date:  2016-05-12       Impact factor: 3.714

Review 4.  The risk-benefit ratio of anticonvulsant drugs.

Authors:  M J Eadie
Journal:  Med Toxicol Adverse Drug Exp       Date:  1987 Sep-Oct

Review 5.  Anticonvulsant drugs. An update.

Authors:  M J Eadie
Journal:  Drugs       Date:  1984-04       Impact factor: 9.546

6.  State of stupor from valproic acid during chronic treatment: case report.

Authors:  S Gentile; C Buffa; C Ravetti; I Sacerdote
Journal:  Ital J Neurol Sci       Date:  1991-04

Review 7.  Valproate-associated hepatotoxicity and its biochemical mechanisms.

Authors:  M J Eadie; W D Hooper; R G Dickinson
Journal:  Med Toxicol Adverse Drug Exp       Date:  1988 Mar-Apr

Review 8.  Valproate hepatotoxicity syndrome: hypotheses of pathogenesis.

Authors:  J R Stephens; R H Levy
Journal:  Pharm Weekbl Sci       Date:  1992-06-19

Review 9.  Interorgan ammonia trafficking in liver disease.

Authors:  Steven W M Olde Damink; Rajiv Jalan; Cornelius H C Dejong
Journal:  Metab Brain Dis       Date:  2008-12-09       Impact factor: 3.584

10.  Valproic Acid-induced hyperammonemia in the elderly: a review of the literature.

Authors:  Vikrant Mittal; Sunanda Muralee; Rajesh R Tampi
Journal:  Case Rep Med       Date:  2009-08-19
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