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Literature DB >> 6411488

The effect of digitoxose on feeding behavior.

Abstract

The effect of digitoxose (DIG) on food intake, gold thioglucose (GTG) lesion formation in the ventromedial hypothalamus (VMH), and VMH glucose oxidation in vitro was investigated in mice. DIG significantly decreased the amount of food ingested during the day compared to controls (p less than 0.01). DIG had no effect on nocturnal feeding. GTG lesion formation in the VMH and VMH glucose oxidation were not altered by DIG treatment. These results suggest that DIG alters daytime feeding behavior by affecting extrahypothalamic or peripheral glucoreceptor sites.

Entities: Chemical Disease Species

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Year: 1983 PMID： 6411488 DOI： 10.1007/BF01989763

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

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References

26 in total

The effect of digitoxose on feeding behavior.

1. Regulation of energy intake and the body weight: the glucostatic theory and the lipostatic hypothesis.

2. Suprachiasmatic nucleus: use of 14C-labeled deoxyglucose uptake as a functional marker.

3. Evidence for the effect of tryptophan on the pattern of food consumption in free feeding and food deprived rats.

4. Ultrastructural changes induced in the hypothalamus of the mouse by goldthioglucose.

5. Gold thioglucose damage to the satiety center: inhibition in diabetes.

6. Hyperphagia caused by cerebral ventricular infusion of phloridzin.

7. Infusion of 2-deoxy-D-glucose into the hepatic-portal system causes eating: evidence for peripheral glucoreceptors.

8. Effects of diet upon hypothalamic vulnerability to goldthioglucose in male mice.

9. Systemic phlorizin prevents gold thioglucose necrosis in the ventromedial hypothalamus.