Literature DB >> 6411325

The inhibitory effects of ethoxyquin on the carcinogenic action of aflatoxin B1 in rats.

J R Cabral, G E Neal.   

Abstract

Ethoxyquin (EQ), a widely used antioxidant, inhibits the carcinogenic effects of polycyclic aromatic hydrocarbons. The aim of the present study was to determine whether EQ modifies the hepatocarcinogenic effects of aflatoxin B1 (AFB1) in rats. Both compounds were administered in the diet. Rats were fed either EQ for 2 weeks and then AFB1 for 6 weeks, EQ and AFB1 simultaneously or EQ following the cessation of AFB1 treatment. The results indicate that EQ can inhibit the hepatocarcinogenic effects of AFB1 and that the most effective inhibition is obtained when EQ and AFB1 are given simultaneously.

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Year:  1983        PMID： 6411325     DOI： 10.1016/0304-3835(83)90146-5

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  8 in total

Review 1.  NRF2, cancer and calorie restriction.

Authors:  A Martín-Montalvo; J M Villalba; P Navas; R de Cabo
Journal:  Oncogene       Date:  2010-11-08       Impact factor: 9.867

2.  Determinants of specificity for aflatoxin B1-8,9-epoxide in alpha-class glutathione S-transferases.

Authors:  P D McDonagh; D J Judah; J D Hayes; L Y Lian; G E Neal; C R Wolf; G C Roberts
Journal:  Biochem J       Date:  1999-04-01       Impact factor: 3.857

Review 3.  Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology.

Authors:  Thomas W Kensler; Bill D Roebuck; Gerald N Wogan; John D Groopman
Journal:  Toxicol Sci       Date:  2010-09-29       Impact factor: 4.849

4.  An ethoxyquin-inducible aldehyde reductase from rat liver that metabolizes aflatoxin B1 defines a subfamily of aldo-keto reductases.

Authors:  E M Ellis; D J Judah; G E Neal; J D Hayes
Journal:  Proc Natl Acad Sci U S A       Date:  1993-11-01       Impact factor: 11.205

5.  Ethoxyquin-induced resistance to aflatoxin B1 in the rat is associated with the expression of a novel alpha-class glutathione S-transferase subunit, Yc2, which possesses high catalytic activity for aflatoxin B1-8,9-epoxide.

Authors:  J D Hayes; D J Judah; L I McLellan; L A Kerr; S D Peacock; G E Neal
Journal:  Biochem J       Date:  1991-10-15       Impact factor: 3.857

6.  Induced expression of drug metabolizing enzymes by preventive agents: role of the antioxidant response element.

Authors:  Ronald A Lubet; Ruisheng Yao; Clinton J Grubbs; Ming You; Yian Wang
Journal:  Chem Biol Interact       Date:  2009-08-18       Impact factor: 5.192

Review 7.  Chemoprevention by inducers of carcinogen detoxication enzymes.

Authors:  T W Kensler
Journal:  Environ Health Perspect       Date:  1997-06       Impact factor: 9.031

Review 8.  Ethoxyquin: An Antioxidant Used in Animal Feed.

Authors:  Alina Błaszczyk; Aleksandra Augustyniak; Janusz Skolimowski
Journal:  Int J Food Sci       Date:  2013-04-30
  8 in total

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