Literature DB >> 6411322

The effects of total-body hyperthermia combined with anticancer drugs on immunity in advanced cancer patients.

S Koga, A Izumi, M Maeta, N Shimizu, Y Osaki, H Kanayama.   

Abstract

As total-body hyperthermia (TBHT) therapy may lead to a reduction in the immune response of cancer patients because of the immediate effect of heat on lymphocytes, the authors studied the immunity of advanced cancer patients receiving combined TBHT and anticancer chemotherapy. A decrease was found in their lymphocyte blastogenesis, skin reactions to PPD and PHA, lymphocyte rosette formation, IgG, and C3c component. These parameters returned to their pretreatment levels at 1 week after completion of TBHT therapy. This result indicates that there is no necessity for giving special consideration to a reduction of cell-mediated immunity in TBHT therapy.

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Year:  1983        PMID： 6411322     DOI： 10.1002/1097-0142(19831001)52:7<1173::aid-cncr2820520708>3.0.co;2-0

Source DB:  PubMed          Journal:  Cancer        ISSN： 0008-543X            Impact factor:   6.860


  5 in total

1.  The effects of extracorporeal whole body hyperthermia on the functional and phenotypic features of canine peripheral blood mononuclear cells (PBMC).

Authors:  R J Kearns; S Ringler; S Krakowka; R Tallman; J Sites; M J Oglesbee
Journal:  Clin Exp Immunol       Date:  1999-04       Impact factor: 4.330

2.  [Effect of local moderate hyperthermia in combination with N-nitroso-1,3-bis-(2-chloroethyl)urea (BCNU) and 5-fluoro-(tetrahydro-2-furyl)uracil (ftorafur) on induced autochthonous colonic cancers in the rat. 3: Polychemotherapy in combination with hyperthermia].

Authors:  E Biwer; M Lorenz; M Habs; D Schmähl
Journal:  Langenbecks Arch Chir       Date:  1984

3.  Whole-body hyperthermia decreases lung metastases in lung tumor-bearing mice, possibly via a mechanism involving natural killer cells.

Authors:  R N Shen; N B Hornback; H Shidnia; R E Shupe; Z Brahmi
Journal:  J Clin Immunol       Date:  1987-05       Impact factor: 8.317

Review 4.  Diverse immune mechanisms may contribute to the survival benefit seen in cancer patients receiving hyperthermia.

Authors:  Adrienne J Peer; Melissa J Grimm; Evan R Zynda; Elizabeth A Repasky
Journal:  Immunol Res       Date:  2010-03       Impact factor: 2.829

5.  The influence of hyperthermia in vitro on the functions of peritoneal macrophages in mice.

Authors:  H Yoshioka; S Koga; M Maeta; N Shimizu; R Hamazoe; A Murakami
Journal:  Jpn J Surg       Date:  1990-01
  5 in total

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