| Literature DB >> 6411287 |
Abstract
A benzodiazepine antagonist, Ro 15-1788, completely abolishes the sedative/ataxic effects of diazepam but, at the same dose (10 mg/kg, i.p.), it, like diazepam, slows the development of kindled seizures. This suggests that the anticonvulsant and sedative effects of benzodiazepines are mediated via different receptors and that Ro 15-1788 or similar compounds may be useful anticonvulsants.Entities:
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Year: 1983 PMID： 6411287 DOI： 10.1016/0006-8993(83)90619-4
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252