Literature DB >> 6411096

Pharmacological effects of non-steroidal antiinflammatory agents on prostaglandin and leukotriene synthesis in mouse peritoneal macrophages.

J L Humes, S Sadowski, M Galavage, M Goldenberg, E Subers, F A Kuehl, R J Bonney.   

Abstract

Resident mouse peritoneal macrophages, exposed to zymosan, synthesized and released products of both the cyclooxygenase and lipoxygenase pathways. The effects of various non-steroidal antiinflammatory agents were evaluated for their abilities to inhibit zymosan-stimulated prostaglandin E2 (PGE2) and leukotriene C4 (LTC4) synthesis. The order of potencies to inhibit PGE2 synthesis and release was: indomethacin greater than or equal to sulindac sulfide greater than ibuprofen greater than or equal to aspirin greater than 3-amino-1-[3-(trifluoromethyl)-phenyl]-2-pyrazoline (BW755C) greater than benoxaprofen greater than or equal to nordihydroguaiaretic acid (NDGA) greater than 5,8,11-eicosatriynoic acid (ETYA). BW755C and ETYA also inhibited zymosan-stimulated LTC4 production. None of the compounds tested showed selective inhibition of lipoxygenase products.

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Year:  1983        PMID： 6411096     DOI： 10.1016/0006-2952(83)90179-x

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  13 in total

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Authors:  M L Sherman; B L Weber; R Datta; D W Kufe
Journal:  J Clin Invest       Date:  1990-02       Impact factor: 14.808

2.  Reduction of lipoxygenase products in psoriatic skin homogenates by QA 208-199.

Authors:  J Schnyder; T Hunziker; M Strasser; B Richardson; A Krebs
Journal:  Arch Dermatol Res       Date:  1986       Impact factor: 3.017

3.  The effects of bleomycin on alveolar macrophage growth factor secretion.

Authors:  E M Denholm; S H Phan
Journal:  Am J Pathol       Date:  1989-02       Impact factor: 4.307

Review 4.  The role of prostaglandins in altered leukocyte function in multiple sclerosis.

Authors:  P Dore-Duffy; S Y Ho; M Longo
Journal:  Springer Semin Immunopathol       Date:  1985

5.  Biosynthesis of paf-acether. Paf-acether but not leukotriene C4 production is impaired in cultured macrophages.

Authors:  A Dulioust; E Vivier; N Meslier; R Roubin; I Haye-Legrand; J Benveniste
Journal:  Biochem J       Date:  1989-10-01       Impact factor: 3.857

6.  Pharmacological control of leukotriene and prostaglandin production from mouse peritoneal macrophages.

Authors:  K Brune; U Aehringhaus; B A Peskar
Journal:  Agents Actions       Date:  1984-06

7.  Renal handling and effects of S(+)-ibuprofen and R(-)-ibuprofen in the rat isolated perfused kidney.

Authors:  P G Cox; W M Moons; F G Russel; C A van Ginneken
Journal:  Br J Pharmacol       Date:  1991-06       Impact factor: 8.739

8.  Pharmacological characterization of mediators and vagal influence in the acute allergic bronchoconstriction in guinea pigs.

Authors:  M H Vargas; L M Montaño; B Vanda; P Segura; M Selman
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-09       Impact factor: 3.000

9.  Immune-complex-induced inflammatory reaction studied by intravital microscopy: role of histamine and arachidonic acid metabolites.

Authors:  J Björk; G Smedegård
Journal:  Inflammation       Date:  1987-03       Impact factor: 4.092

10.  Terameprocol, a methylated derivative of nordihydroguaiaretic acid, inhibits production of prostaglandins and several key inflammatory cytokines and chemokines.

Authors:  D Eads; Rl Hansen; Ao Oyegunwa; Ce Cecil; Ca Culver; F Scholle; Itd Petty; Sm Laster
Journal:  J Inflamm (Lond)       Date:  2009-01-08       Impact factor: 4.981
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