Literature DB >> 6411091

Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets.

J R Falck, S Manna, J Moltz, N Chacos, J Capdevila.   

Abstract

Metapyrone and eicosatetraynoic acid but not indomethacin are effective inhibitors of the secretory response of isolated rat pancreatic islets to arginine and glucose. Epoxyeicosatrienoic acids, products of the cytochrome P-450-NADPH dependent arachidonic acid epoxygenase activity, are potent and selective mediators for the in vitro release of either insulin or glucagon from preparations of isolated rat pancreatic islets.

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Year:  1983        PMID： 6411091     DOI： 10.1016/0006-291x(83)90843-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  35 in total

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Review 2.  The Role of Cytochrome P450 Epoxygenases, Soluble Epoxide Hydrolase, and Epoxyeicosatrienoic Acids in Metabolic Diseases.

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4.  Epoxyeicosatrienoic acids mediate insulin-mediated augmentation in skeletal muscle perfusion and blood volume.

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Journal:  Drug Metab Dispos       Date:  2013-01-11       Impact factor: 3.922

9.  20-HETE attenuates the response of glucose-stimulated insulin secretion through the AKT/GSK-3β/Glut2 pathway.

Authors:  Bijun Zhang; Guangrui Lai; Jingjing Wu; Ru Sun; Runhong Xu; Xianghong Yang; Yafei Qi; Yanyan Zhao
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Review 10.  Epoxyeicosatrienoic acids and glucose homeostasis in mice and men.

Authors:  James M Luther; Nancy J Brown
Journal:  Prostaglandins Other Lipid Mediat       Date:  2016-07-19       Impact factor: 3.072
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