CT characteristics of a transplantable canine glioma model: preliminary kinetic analysis.

Experimental brain tumors can be produced in dogs through the intracerebral injection of 3 X 10(6) live tumor cells in either neonates or adult animals. Tumors are visible by computed tomography on day 8 postinjection. Most tumors appear as ring lesions with central lucencies and shaggy borders. By postinjection day 12, tumor volumes increase more than 10 times; the cell cycling time is about 1-3 days. The initial doubling time is about 1-2 days and corresponds to the in vitro doubling time of about 24 hr. The use of computed tomography to perform noninvasive kinetic analysis deserves further study. The transplantable canine glioma model would appear to be ideal for this purpose.