Literature DB >> 6410283

Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster.

M Kreitman.   

Abstract

The sequencing of eleven cloned Drosophila melanogaster alcohol dehydrogenase (Adh) genes from five natural populations has revealed a large number of previously hidden polymorphisms. Only one of the 43 polymorphisms results in an amino acid change, the one responsible for the two electrophoretic variants (fast, Adh-f, and slow, Adh-s) found in nearly all natural populations. The implication is that most amino acid changes in Adh would be selectively deleterious.

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Year:  1983        PMID： 6410283     DOI： 10.1038/304412a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  213 in total

1.  Protein variation in Adh and Adh-related in Drosophila pseudoobscura. Linkage disequilibrium between single nucleotide polymorphisms and protein alleles.

Authors:  S W Schaeffer; C S Walthour; D M Toleno; A T Olek; E L Miller
Journal:  Genetics       Date:  2001-10       Impact factor: 4.562

2.  Contrasting patterns of nonneutral evolution in proteins encoded in nuclear and mitochondrial genomes.

Authors:  D M Weinreich; D M Rand
Journal:  Genetics       Date:  2000-09       Impact factor: 4.562

3.  Natural selection and the frequency distributions of "silent" DNA polymorphism in Drosophila.

Authors:  H Akashi; S W Schaeffer
Journal:  Genetics       Date:  1997-05       Impact factor: 4.562

4.  Polymorphism and locus-specific effects on polymorphism at microsatellite loci in natural Drosophila melanogaster populations.

Authors:  C Schlötterer; C Vogl; D Tautz
Journal:  Genetics       Date:  1997-05       Impact factor: 4.562

5.  On the minimum number of recombination events in the evolutionary history of DNA sequences.

Authors:  Yun S Song; Jotun Hein
Journal:  J Math Biol       Date:  2003-08-20       Impact factor: 2.259

6.  Polymorphism, recombination and alternative unscrambling in the DNA polymerase alpha gene of the ciliate Stylonychia lemnae (Alveolata; class Spirotrichea).

Authors:  David H Ardell; Catherine A Lozupone; Laura F Landweber
Journal:  Genetics       Date:  2003-12       Impact factor: 4.562

7.  Estimation of levels of gene flow from DNA sequence data.

Authors:  R R Hudson; M Slatkin; W P Maddison
Journal:  Genetics       Date:  1992-10       Impact factor: 4.562

8.  Compensatory evolution of a precursor messenger RNA secondary structure in the Drosophila melanogaster Adh gene.

Authors:  Ying Chen; Wolfgang Stephan
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-12       Impact factor: 11.205

9.  Cloned Drosophila alcohol dehydrogenase genes are correctly expressed after transfection into Drosophila cells in culture.

Authors:  C Benyajati; J F Dray
Journal:  Proc Natl Acad Sci U S A       Date:  1984-03       Impact factor: 11.205

10.  Nucleotide sequence comparison of the Adh gene in three drosophilids.

Authors:  V H Cohn; M A Thompson; G P Moore
Journal:  J Mol Evol       Date:  1984       Impact factor: 2.395
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