Literature DB >> 6409971

Production and characterization of anti-murine interferon-gamma sera.

E A Havell, G L Spitalny.   

Abstract

A partially purified phytohaemagglutinin (PHA)-induced spleen cell murine interferon-gamma (MuIFN-gamma) proved a potent immunogen in a rabbit and rats. Neutralizing anti-MuIFN-gamma activity was detected in rabbit serum following two biweekly subcutaneous inoculations of MuIFN-gamma emulsified in Freund's complete adjuvant. Further biweekly injections of immunogen in Freund's incomplete adjuvant, greatly elevated the serum anti-MuIFN-gamma neutralizing titer. Inbred DA rats also responded with serum neutralizing antibodies for MuIFN-gamma. Rabbit and rat anti-MuIFN-gamma sera neutralized the antiviral activities of MuIFN-gamma preparations produced by T-cells in response to different polyclonal T-cell mitogens or by sensitized T-cells stimulated with specific antigen(s). In addition, the antiviral activity of a rat IFN-gamma on murine cells was neutralized by rabbit anti-MuIFN-gamma serum, but not by the rat anti-MuIFN-gamma serum.

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Year:  1983        PMID： 6409971     DOI： 10.1089/jir.1983.3.191

Source DB:  PubMed          Journal:  J Interferon Res        ISSN： 0197-8357


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