Literature DB >> 6409918

Effects of a growth hormone releasing factor in man.

M C Gelato, O Pescovitz, F Cassorla, D L Loriaux, G R Merriam.   

Abstract

The effects of the 44-amino acid growth hormone releasing factor (GRF-44) were tested in normal adult men and women. At a dose of 1 microgram/kg, intravenous boluses of GRF-44 stimulated prompt elevations of plasma GH, which in 5 men reached maximum levels of 34 +/- 28 (S.D.) ng/ml, and in 3 women in the mid-follicular phase, 53 +/- 10 ng/ml. The action of GRF was highly selective; there were no changes in plasma PRL, LH, FSH, TSH, or cortisol at this dose level. Side effects, mostly flushing and a sense of warmth of the face and chest, were mild and occurred only in a minority of subjects.

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Year:  1983        PMID： 6409918     DOI： 10.1210/jcem-57-3-674

Source DB:  PubMed          Journal:  J Clin Endocrinol Metab        ISSN： 0021-972X            Impact factor:   5.958


  12 in total

Review 1.  Neuroendocrine regulation of human growth hormone secretion. Diagnostic and clinical applications.

Authors:  G Delitala; P Tomasi; R Virdis
Journal:  J Endocrinol Invest       Date:  1988-06       Impact factor: 4.256

2.  Human pancreatic tumor GH-releasing factor.

Authors:  M O Thorner; W S Evans; M Vance; J L Borges; R M Blizzard; A D Rogol; R M MacLeod; M J Cronin; L A Frohman; J L Thominet
Journal:  Acta Neurochir (Wien)       Date:  1985       Impact factor: 2.216

3.  Human pancreatic growth hormone-releasing factor (hpGRF-44) in acromegaly before and after adenomectomy. Modifications induced by somatostatin (GHRIH) infusion.

Authors:  M Arosio; B Ambrosi; L Guglielmino; G Faglia
Journal:  J Endocrinol Invest       Date:  1985-10       Impact factor: 4.256

4.  Growth-hormone releasing factor and clonidine in children with constitutional growth delay. Evidence for defective pituitary growth hormone reserve.

Authors:  C Pintor; R Puggioni; V Fanni; S G Cella; A Villa; V Locatelli; E E Müller
Journal:  J Endocrinol Invest       Date:  1984-06       Impact factor: 4.256

5.  Circulating growth hormone releasing factor concentrations in normal subjects and patients with acromegaly.

Authors:  E S Penny; E Penman; J Price; L H Rees; A M Sopwith; J A Wass; N Lytras; G M Besser
Journal:  Br Med J (Clin Res Ed)       Date:  1984-08-25

6.  Study on the mechanism of abnormal growth hormone (GH) secretion in anorexia nervosa: no evidence of involvement of a low somatomedin-C level in the abnormal GH secretion.

Authors:  A Masuda; T Shibasaki; M Hotta; H Suematsu; K Shizume
Journal:  J Endocrinol Invest       Date:  1988-04       Impact factor: 4.256

7.  The effect of GHRH on TSH release in rats in vivo and in vitro.

Authors:  B J Looij; A C Nieuwenhuijzen Kruseman; F Roelfsema; D van der Heide; R P Hoogma; J P Schröder-van der Elst
Journal:  J Endocrinol Invest       Date:  1995-03       Impact factor: 4.256

8.  The effects of growth hormone-releasing factor (GRF) and dopamine on growth hormone (GH) secretion in acromegaly.

Authors:  M Giusti; A Lomeo; G Mazzocchi; D Mignone; P Sessarego; M Monachesi; G Giordano
Journal:  J Endocrinol Invest       Date:  1985-06       Impact factor: 4.256

9.  Correlation between pituitary growth hormone reserve and degree of growth failure in children with short stature.

Authors:  S Kajiwara; N Igarashi; E Imura; T Sato
Journal:  Eur J Pediatr       Date:  1988-08       Impact factor: 3.183

10.  Rapid effect of intravenous growth hormone (GH)-releasing hormone 1-44 on plasma GH levels in children.

Authors:  R Rosskamp; F Haverkamp
Journal:  Eur J Pediatr       Date:  1988-10       Impact factor: 3.183
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