Oral treatment of hemophilia A using traditional kanpo medicine, Huang-lien-chieh-tu-tang (plant extract).

Huang-lien-chieh-tu-tang (HLCT) extract was given orally to a patient with severe hemophilia A. The plasma concentration of factor VIII rose from less than 1 to 41% 1 h after oral administration of HLCT extract. APTT also decreased from 102.0 to 70.9 s. In vitro experiments, HLCT showed factor VIII, IX and X biological activity at concentrations around 0.08%. There was no factor-VIII-antigen-related activity in HLCT.