Literature DB >> 6409078

Effects of glucose on phosphorylase and glycogen synthase in hepatocytes from diabetic rats.

M Bollen, L Hue, W Stalmans.   

Abstract

The effects of glucose on phosphorylase and glycogen synthase were investigated in hepatocytes isolated from acutely (40 h) and chronically (90 h) alloxan-diabetic rats. The glucose-induced inactivation of phosphorylase proceeded normally in all conditions. The ensuing activation of glycogen synthase was slightly blunted in acute diabetes, but became virtually absent in 72 h diabetes of similar severity. In hepatocytes from rats with various degrees of chronic diabetes, the maximal activation of glycogen synthase (at 60 mM-glucose) was inversely correlated with the plasma glucose concentration.

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Year:  1983        PMID： 6409078      PMCID： PMC1154290          DOI： 10.1042/bj2100783

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  17 in total

1.  The sequential inactivation of glycogen phosphorylase and activation of glycogen synthetase in liver after the administration of glucose to mice and rats. The mechanism of the hepatic threshold to glucose.

Authors:  W Stalmans; H De Wulf; L Hue; H G Hers
Journal:  Eur J Biochem       Date:  1974-01-03

2.  Mechanism of control of hepatic glycogenesis by insulin.

Authors:  T B Miller; J Larner
Journal:  J Biol Chem       Date:  1973-05-25       Impact factor: 5.157

3.  The relationship between insulin and apparent glucocorticoid-promoted activation of hepatic glycogen synthetase.

Authors:  W K Nichols; N D Goldberg
Journal:  Biochim Biophys Acta       Date:  1972-09-15

4.  Insulin regulation of hepatic glycogen metabolism in the dog.

Authors:  J S Bishop; N D Goldberg; J Larner
Journal:  Am J Physiol       Date:  1971-02

5.  An absolute requirement for insulin in the control of hepatic glycogenesis by glucose.

Authors:  T B Miller; R Hazen; J Larner
Journal:  Biochem Biophys Res Commun       Date:  1973-07-17       Impact factor: 3.575

6.  The effect of diabetes and insulin on liver glycogen synthetase activation.

Authors:  A H Gold
Journal:  J Biol Chem       Date:  1970-02-25       Impact factor: 5.157

7.  Synthesis of liver glycogen in starved alloxan diabetic rats.

Authors:  K R Hornbrook
Journal:  Diabetes       Date:  1970-12       Impact factor: 9.461

8.  Dependence on insulin of the apparent hydrocortisone activation of hepatic glycogen synthetase.

Authors:  W Kreutner; N D Goldberg
Journal:  Proc Natl Acad Sci U S A       Date:  1967-10       Impact factor: 11.205

9.  The effects of glucose and of potassium ions on the interconversion of the two forms of glycogen phosphorylase and of glycogen synthetase in isolated rat liver preparations.

Authors:  L Hue; F Bontemps; H Hers
Journal:  Biochem J       Date:  1975-10       Impact factor: 3.857

10.  Regulation of synthase phosphatase and phosphorylase phosphatase in rat liver.

Authors:  A W Tan; F Q Nuttall
Journal:  Biochim Biophys Acta       Date:  1976-08-12
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  10 in total

1.  Oral administration of vanadate to streptozotocin-diabetic rats restores the glucose-induced activation of liver glycogen synthase.

Authors:  M Bollen; M Miralpeix; F Ventura; B Toth; R Bartrons; W Stalmans
Journal:  Biochem J       Date:  1990-04-01       Impact factor: 3.857

2.  Effect of feeding aqueous extract of Pterocarpus marsupium on glycogen content of tissues and the key enzymes of carbohydrate metabolism.

Authors:  Jagdish Kumari Grover; Vikrant Vats; Satyapal Yadav
Journal:  Mol Cell Biochem       Date:  2002-12       Impact factor: 3.396

3.  Differences in liver glycogen-synthase phosphatase activity in rodents with spontaneous insulin-dependent and non-insulin-dependent diabetes.

Authors:  M Bollen; S Keppens; W Stalmans
Journal:  Diabetologia       Date:  1988-09       Impact factor: 10.122

4.  Glucose-induced glycogenesis in the liver involves the glucose-6-phosphate-dependent dephosphorylation of glycogen synthase.

Authors:  J Cadefau; M Bollen; W Stalmans
Journal:  Biochem J       Date:  1997-03-15       Impact factor: 3.857

5.  Fasting enhances glycogen synthase activation in hepatocytes from insulin-resistant genetically obese (fa/fa) rats.

Authors:  G van de Werve
Journal:  Biochem J       Date:  1990-08-01       Impact factor: 3.857

6.  The hepatic defect in glycogen synthesis in chronic diabetes involves the G-component of synthase phosphatase.

Authors:  M Bollen; W Stalmans
Journal:  Biochem J       Date:  1984-01-15       Impact factor: 3.857

7.  Identification of the glycogenic compound 5-iodotubercidin as a general protein kinase inhibitor.

Authors:  D Massillon; W Stalmans; G van de Werve; M Bollen
Journal:  Biochem J       Date:  1994-04-01       Impact factor: 3.857

8.  The activity of glycogen synthase phosphatase limits hepatic glycogen deposition in the adrenalectomized starved rat.

Authors:  M Bollen; G Gevers; W Stalmans
Journal:  Biochem J       Date:  1983-08-15       Impact factor: 3.857

9.  Stimulation of glycogen synthesis and lipogenesis by glutamine in isolated rat hepatocytes.

Authors:  A Lavoinne; A Baquet; L Hue
Journal:  Biochem J       Date:  1987-12-01       Impact factor: 3.857

10.  Effects of C-1-substituted glucose analogue on the activation states of glycogen synthase and glycogen phosphorylase in rat hepatocytes.

Authors:  M Board; M Bollen; W Stalmans; Y Kim; G W Fleet; L N Johnson
Journal:  Biochem J       Date:  1995-11-01       Impact factor: 3.857
  10 in total

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