| Literature DB >> 6408711 |
J C Sircar, C F Schwender, E A Johnson.
Abstract
Eighteen known nonsteroidal antiinflammatory drugs (NSAID) were tested for their action against soybean lipoxygenase (E.C.1.13.11.12) using linoleic acid as substrate. It was found that the best inhibitors of lipoxygenase were naproxen, BW 755C, indomethacin and isoxicam. Drugs with intermediate potency were meclofenamic acid, phenylbutazone and benoxaprofen. Other drugs such as ibuprofen and zomepirac were only weakly active in the test.Entities:
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Year: 1983 PMID： 6408711 DOI： 10.1016/0090-6980(83)90042-4
Source DB: PubMed Journal: Prostaglandins ISSN： 0090-6980