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Literature DB >> 6408333

Potentiating effect of 5,8,11-eicosatrienoic acid on human platelet aggregation.

M Lagarde, M Burtin, H Sprecher, M Dechavanne, S Renaud.

Abstract

5,8,11-Eicosatrienoic acid (20:3 omega 9), a fatty acid increased in the platelet phospholipids of man and animals fed saturated fats, was either added to human platelets simultaneously with the aggregating agents, or incorporated into the platelet phospholipids by preincubation. 20:3 omega 9 markedly increased the response of platelets to all aggregating agents tested when added simultaneously with the agent, but solely to thrombin and ionophore, after incorporation into the platelet phospholipids. The potentiating effects of 20:3 omega 9 on thrombin aggregation do not appear to be related to prostaglandin formation, but rather to the production of a monohydroxy derivative through the lipoxygenase pathway.

Entities: Chemical Disease Gene Species

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Year: 1983 PMID： 6408333 DOI： 10.1007/BF02534704

Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880

17 in total

1. Ionophores stimulate prostaglandin and thromboxane biosynthesis.

Authors: H R Knapp; O Oelz; L J Roberts; B J Sweetman; J A Oates; P W Reed
Journal: Proc Natl Acad Sci U S A Date: 1977-10 Impact factor: 11.205

2. Abnormal fatty acid composition and human atherosclerosis.

Authors: K J Kingsbury; C Brett; R Stovold; A Chapman; J Anderson; D M Morgan
Journal: Postgrad Med J Date: 1974-07 Impact factor: 2.401

3. Effect of dietary linoleic acid deficiency on platelet aggregation and phospholipid fatty acid of rats.

Authors: L McGregor; S Renaud
Journal: Thromb Res Date: 1978-05 Impact factor: 3.944

4. Study of the two pathways for arachidonate oxygenation in blood platelets.

Authors: C E Dutilh; E Haddeman; G H Jouvenaz; F Ten Hoor; D H Nugteren
Journal: Lipids Date: 1979-02 Impact factor: 1.880

5. The synthesis of 1-14C-arachidonate and 3-14C-docosa-7,10,13,16-tetraenoate.

Authors: H Sprecher
Journal: Lipids Date: 1971-12 Impact factor: 1.880

6. The phospholipid and fatty acid composition of human platelet surface and intracellular membranes isolated by high voltage free flow electrophoresis.

Authors: M Lagarde; M Guichardant; S Menashi; N Crawford
Journal: J Biol Chem Date: 1982-03-25 Impact factor: 5.157

7. The ratio of trienoic: tetraenoic acids in tissue lipids as a measure of essential fatty acid requirement.

Authors: R T Holman
Journal: J Nutr Date: 1960-03 Impact factor: 4.798

8. Dihomogammalinolenic acid (20:3 omega 6) is more anti-aggregatory than eicosapentaenoic (20:5 omega 3) in a platelet-endothelial cell mixture.

Authors: M Lagarde; M Burtin; M Dechavanne; B Sicard; B Coiffier
Journal: Prostaglandins Med Date: 1980-03

9. A comparison of the effects of dietary short and long chain saturated fatty acids on platelet functions, platelet phospholipids, and blood coagulation in rats.

Authors: L McGregor; R Morazain; S Renaud
Journal: Lab Invest Date: 1980-11 Impact factor: 5.662

10. Selective inhibitors of platelet lipoxygenase: 4,7,10,13-eicosatetraynoic acid and 5,8,11,14-henicosatetraynoic acid.

Authors: T E Wilhelm; S K Sankarappa; M VanRollins; H Sprecher
Journal: Prostaglandins Date: 1981-02

7 in total

1. Eskimo plasma constituents, dihomo-gamma-linolenic acid, eicosapentaenoic acid and docosahexaenoic acid inhibit the release of atherogenic mitogens.

Authors: D L Smith; A L Willis; N Nguyen; D Conner; S Zahedi; J Fulks
Journal: Lipids Date: 1989-01 Impact factor: 1.880

Potentiating effect of 5,8,11-eicosatrienoic acid on human platelet aggregation.

1. Ionophores stimulate prostaglandin and thromboxane biosynthesis.

2. Abnormal fatty acid composition and human atherosclerosis.

3. Effect of dietary linoleic acid deficiency on platelet aggregation and phospholipid fatty acid of rats.

4. Study of the two pathways for arachidonate oxygenation in blood platelets.

5. The synthesis of 1-14C-arachidonate and 3-14C-docosa-7,10,13,16-tetraenoate.

6. The phospholipid and fatty acid composition of human platelet surface and intracellular membranes isolated by high voltage free flow electrophoresis.

7. The ratio of trienoic: tetraenoic acids in tissue lipids as a measure of essential fatty acid requirement.

8. Dihomogammalinolenic acid (20:3 omega 6) is more anti-aggregatory than eicosapentaenoic (20:5 omega 3) in a platelet-endothelial cell mixture.

9. A comparison of the effects of dietary short and long chain saturated fatty acids on platelet functions, platelet phospholipids, and blood coagulation in rats.

10. Selective inhibitors of platelet lipoxygenase: 4,7,10,13-eicosatetraynoic acid and 5,8,11,14-henicosatetraynoic acid.

1. Eskimo plasma constituents, dihomo-gamma-linolenic acid, eicosapentaenoic acid and docosahexaenoic acid inhibit the release of atherogenic mitogens.

2. Genomic Insights into Omega-3 Polyunsaturated Fatty Acid Producing Shewanella sp. N2AIL from Fish Gut.

3. Effects of dietary fats on prostanoid production and aortic and plasma fatty acid composition in rats.

4. Butter-enriched diets reduce arterial prostacyclin production in rats.

5. Fatty acid composition of umbilical arteries and veins: possible implications for the fetal EFA-status.

Review 6. Omega-9 fatty acids: potential roles in inflammation and cancer management.

Review 7. Microbes: A Hidden Treasure of Polyunsaturated Fatty Acids.