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Literature DB >> 6407113

A gene controlling condensation of heterochromatin in Drosophila melanogaster.

Abstract

A temperature-sensitive lethal mutant of Drosophila melanogaster was used to identify an essential cell cycle function that is necessary for the mitotic condensation of heterochromatic but not of euchromatic portions of the genome. This mutant is an allele at a locus (mus-101) identified earlier by the use of mutagen-sensitive mutants. The data suggest that the mutagen-sensitive and repair-defective phenotypes of viable mus-101 mutants result from a disruption in chromosome organization.

Entities: Gene Species

Mesh：

Substances：
Heterochromatin

Year: 1983 PMID： 6407113 DOI： 10.1126/science.6407113

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

17 in total

1. Antibodies to defined histone epitopes reveal variations in chromatin conformation and underacetylation of centric heterochromatin in human metaphase chromosomes.

Authors: P Jeppesen; A Mitchell; B Turner; P Perry
Journal: Chromosoma Date: 1992-03 Impact factor: 4.316

2. Sequence-directed curvature of repetitive AluI DNA in constitutive heterochromatin of Artemia franciscana.

Authors: R Benfante; N Landsberger; G Tubiello; G Badaracco
Journal: Nucleic Acids Res Date: 1989-10-25 Impact factor: 16.971

Review 3. DNA Repair in Drosophila: Mutagens, Models, and Missing Genes.

Authors: Jeff Sekelsky
Journal: Genetics Date: 2017-02 Impact factor: 4.562

4. Trans-acting amplification mutants and other eggshell mutants of the third chromosome in Drosophila melanogaster.

Authors: P B Snyder; V K Galanopoulos; F C Kafatos
Journal: Proc Natl Acad Sci U S A Date: 1986-05 Impact factor: 11.205

5. Immunodeficiency, centromeric heterochromatin instability of chromosomes 1, 9, and 16, and facial anomalies: the ICF syndrome.

Authors: P Maraschio; O Zuffardi; T Dalla Fior; L Tiepolo
Journal: J Med Genet Date: 1988-03 Impact factor: 6.318

A gene controlling condensation of heterochromatin in Drosophila melanogaster.

1. Antibodies to defined histone epitopes reveal variations in chromatin conformation and underacetylation of centric heterochromatin in human metaphase chromosomes.

2. Sequence-directed curvature of repetitive AluI DNA in constitutive heterochromatin of Artemia franciscana.

Review 3. DNA Repair in Drosophila: Mutagens, Models, and Missing Genes.

4. Trans-acting amplification mutants and other eggshell mutants of the third chromosome in Drosophila melanogaster.

5. Immunodeficiency, centromeric heterochromatin instability of chromosomes 1, 9, and 16, and facial anomalies: the ICF syndrome.

6. Mutations in genes encoding essential mitotic functions in Drosophila melanogaster.

7. Systematic, RNA-interference-mediated identification of mus-101 modifier genes in Caenorhabditis elegans.

8. Identification of genomic regions required for DNA replication during Drosophila embryogenesis.

9. Heteropycnosis of an underreplicating chromosome.

10. TopBP1 localises to centrosomes in mitosis and to chromosome cores in meiosis.