Respiratory improvement by muscle training in adult-onset acid maltase deficiency.

A patient with progressive involvement of respiratory function from adult-onset acid maltase deficiency is reported. The decrement in objective and subjective waking and sleeping respiratory variables was significantly reversed by inspiratory muscle training. This training was accomplished simply by breathing against inspiratory resistors for 15 minutes twice a day. Inspiratory muscle training may prove valuable in other patients with progressive neuromuscular disorders that involve respiratory muscle function.