Literature DB >> 6406881

Mutagenicity of 2 anti-chagasic drugs and their metabolic deactivation.

R Nagel, I Nepomnaschy.   

Abstract

2 anti-chagasic drugs, nifurtimox and benznidazole, were assayed in the Salmonella/mammalian microsome test. These drugs were most active in strain TA100. Under certain experimental conditions, addition of rat-liver S9 mix led to a decrease in the number of his+ revertants induced by the drugs.

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Year:  1983        PMID： 6406881     DOI： 10.1016/0165-1218(83)90124-6

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  3 in total

1.  Antitrypanosomal activities and cytotoxicity of some novel imido-substituted 1,4-naphthoquinone derivatives.

Authors:  Mozna H Khraiwesh; Clarence M Lee; Yakini Brandy; Emmanuel S Akinboye; Solomon Berhe; Genelle Gittens; Muneer M Abbas; Franklin R Ampy; Mohammad Ashraf; Oladapo Bakare
Journal:  Arch Pharm Res       Date:  2012-02-02       Impact factor: 4.946

2.  Genotoxicity revaluation of three commercial nitroheterocyclic drugs: nifurtimox, benznidazole, and metronidazole.

Authors:  Annamaria Buschini; Lisa Ferrarini; Susanna Franzoni; Serena Galati; Mirca Lazzaretti; Francesca Mussi; Cristina Northfleet de Albuquerque; Tânia Maria Araújo Domingues Zucchi; Paola Poli
Journal:  J Parasitol Res       Date:  2009-10-21

3.  Insights into Ergosterol Peroxide's Trypanocidal Activity.

Authors:  Thuluz Meza-Menchaca; Angel Ramos-Ligonio; Aracely López-Monteon; Abraham Vidal Limón; Leonid A Kaluzhskiy; Tatjana V Shkel; Natallia V Strushkevich; Luis Felipe Jiménez-García; Lourdes Teresa Agredano Moreno; Verónica Gallegos-García; Jorge Suárez-Medellín; Ángel Trigos
Journal:  Biomolecules       Date:  2019-09-12
  3 in total

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