Literature DB >> 6406259

Effect of spironolactone on p-nitrophenol glucuronidation in isolated rat hepatocytes.

E E Guibert, L S Morisoli, J A Monti, E A Rodriguez Garay.   

Abstract

The effect of spironolactone (SP) on p-nitrophenol (PNP) glucuronidation was studied in isolated rat hepatocytes with appropriate viability conditions. A significant increase of protein concentration and PNP glucuronidation was found in the hepatocytes from SP-treated rats. Increased enzyme activity apparently was related to the SP dose. The results favor the conclusion that SP may induce PNP glucuronidation in the hepatocyte.

Entities:  

Mesh：

Substances：

Year:  1983        PMID： 6406259     DOI： 10.1007/BF01965189

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  25 in total

1.  Relation of oxygen and temperature in the preservation of tissues by refrigeration.

Authors:  J H HANKS; R E WALLACE
Journal:  Proc Soc Exp Biol Med       Date:  1949-06

2.  Swelling-contraction of mitochondria in hypotonic medium.

Authors:  E M Suranyi; Y Avi-Dor
Journal:  Biochim Biophys Acta       Date:  1966-06-15

3.  Effect of spironolactone, pregnenolone-16 -carbonitrile and cortisol on the metabolism and biliary excretion of sulfobromophthalein and phenol-3,6-dibromophthalein disulfonate in rats.

Authors:  G Zsigmond; B Solymoss
Journal:  J Pharmacol Exp Ther       Date:  1972-12       Impact factor: 4.030

4.  Variable effect of phenobarbital treatment of mice on hepatic UDP-glucuronyltransferase activity when judged by slightly different enzyme-assay techniques.

Authors:  A Winsnes
Journal:  Biochem Pharmacol       Date:  1971-08       Impact factor: 5.858

5.  Metabolism of drugs in isolated rat hepatocytes.

Authors:  P T Henderson; J H Dewaide
Journal:  Biochem Pharmacol       Date:  1969-09       Impact factor: 5.858

Review 6.  The metabolism of drugs and other foreign compounds in suspensions of isolated rat hepatocytes.

Authors:  R E McMahon
Journal:  Ann N Y Acad Sci       Date:  1980       Impact factor: 5.691

7.  Modifications of bile secretion and liver microsomal enzymes by aldosterone and spironolactone.

Authors:  F Afifi; M Peignoux; C Auclair
Journal:  Hepatogastroenterology       Date:  1980-02

8.  Stimulation of Rb+ transport by glucagon in isolated rat hepatocytes.

Authors:  M J Ihlenfeldt
Journal:  J Biol Chem       Date:  1981-03-10       Impact factor: 5.157

9.  Effect of spironolactone on bilirubin metabolism in rat liver and small intestinal mucosa.

Authors:  L S Morisoli; A D Mottino; J M Pellegrino; E E Guibert; E A Rodriguez Garay
Journal:  Biochem Pharmacol       Date:  1982-04-15       Impact factor: 5.858

10.  High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.

Authors:  M N Berry; D S Friend
Journal:  J Cell Biol       Date:  1969-12       Impact factor: 10.539
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.