Literature DB >> 6405289

The role of NADP-dependent dehydrogenases in hydroxylation of tyrosine in hamster melanoma.

P W Scisłowski, A Słominski.   

Abstract

The activities of NADP-linked dehydrogenases in the cytosol of amelanotic, black melanotic and brown melanotic hamster melanoma are presented. It has been shown that the tyrosine to DOPA hydroxylation is stimulated by the NADPH produced in the reaction catalyzed by either isocitrate dehydrogenase or glucose-6-phosphate dehydrogenase. The significance of NADPH in the hydroxylation of tyrosine to dopa in hamster melanoma is discussed.

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Year:  1983        PMID： 6405289

Source DB:  PubMed          Journal:  Neoplasma        ISSN： 0028-2685            Impact factor:   2.575


  11 in total

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4.  Melanin content in melanoma metastases affects the outcome of radiotherapy.

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Review 5.  Melanin and lipofuscin as hallmarks of skin aging.

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10.  Melanization as unfavorable factor in amelanotic melanoma cell biology.

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