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Literature DB >> 6404468

Aluminium hydroxide versus sucralfate as a phosphate binder in uraemia.

A C Leung, I S Henderson, D J Halls, J W Dobbie.

Abstract

In an attempt to discover a phosphate binding agent for use in uraemia that would not lead to appreciable systemic absorption of aluminium the effect of sucralfate was evaluated after three weeks and compared with that of the existing standard agent aluminium hydroxide. Sucralfate caused a decrease in serum phosphate concentration comparable with that obtained with aluminium hydroxide, but similar absorption of aluminium resulted. Sucralfate may be the phosphate binder of choice in patients with uraemia and peptic ulceration; care should be taken in using large doses of the drug in patients with normal renal function.

Entities: Chemical Species

Mesh：

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Year: 1983 PMID： 6404468 PMCID： PMC1547820 DOI： 10.1136/bmj.286.6375.1379

Source DB: PubMed Journal: Br Med J (Clin Res Ed) ISSN： 0267-0623

14 in total

1. The dialysis encephalopathy syndrome. Possible aluminum intoxication.

Authors: A C Alfrey; G R LeGendre; W D Kaehny
Journal: N Engl J Med Date: 1976-01-22 Impact factor: 91.245

2. Composition of the domestic water supply and the incidence of fractures and encephalopathy in patients on home dialysis.

Authors: M M Platts; G C Goode; J S Hislop
Journal: Br Med J Date: 1977-09-10

3. Hyperaluminaemia from aluminum resins in renal failure.

Authors: G M Berlyne; J Ben-Ari; D Pest; J Weinberger; M Stern; R Levine; G R Gilmore
Journal: Lancet Date: 1970-09-05 Impact factor: 79.321

4. Gastrointestinal absorption of aluminum from aluminum-containing antacids.

Authors: W D Kaehny; A P Hegg; A C Alfrey
Journal: N Engl J Med Date: 1977-06-16 Impact factor: 91.245

5. The effect of oral aluminium therapy on plasma aluminium levels in patients with chronic renal failure in an area with low water aluminium.

Authors: L W Fleming; W k Stewart; G S Fell; D J Halls
Journal: Clin Nephrol Date: 1982-05 Impact factor: 0.975

Aluminium hydroxide versus sucralfate as a phosphate binder in uraemia.

1. The dialysis encephalopathy syndrome. Possible aluminum intoxication.

2. Composition of the domestic water supply and the incidence of fractures and encephalopathy in patients on home dialysis.

3. Hyperaluminaemia from aluminum resins in renal failure.

4. Gastrointestinal absorption of aluminum from aluminum-containing antacids.

5. The effect of oral aluminium therapy on plasma aluminium levels in patients with chronic renal failure in an area with low water aluminium.

6. Adverse effects of aluminum-containing antacids on mineral metabolism.

7. Serum aluminum and continuous ambulatory peritoneal dialysis.

8. Osteomalacic dialysis osteodystrophy: Evidence for a water-borne aetiological agent, probably aluminium.

9. Efficacy of sucralfate for duodenal ulcers: a multicenter, double-blind trial.

10. Aluminium toxicity during regular haemodialysis.

Review 1. Clinical pharmacokinetics of drugs used in the treatment of gastrointestinal diseases (Part II).

Review 2. Assessing the safety of drugs for the long-term treatment of peptic ulcers.

Review 3. Antacid and sucralfate-induced hypophosphatemic osteomalacia: a case report and review of the literature.

Review 4. Renal effects of peptic ulcer therapy.

Review 5. Sucralfate. A review of its pharmacodynamic properties and therapeutic use in peptic ulcer disease.

Review 6. Pharmacokinetic optimisation of the treatment of peptic ulcer in patients with renal failure.

Review 7. Science review: The use of proton pump inhibitors for gastric acid suppression in critical illness.

Review 8. Drug-Dosing Adjustment in Dogs and Cats with Chronic Kidney Disease.

9. ACVIM consensus statement: Support for rational administration of gastrointestinal protectants to dogs and cats.