Literature DB >> 6404261

Inhibition of histidine decarboxylase and tumour promoter-induced arachidonic acid release by lecanoric acid analogues.

K Umezawa, S Muramatsu, M Ishizuka, T Sawa, T Takeuchi, T Matsushima.   

Abstract

Lecanoric acid analogues containing benzanilide structure inhibited histidine decarboxylase and arachidonic acid release from the cell membrane phospholipids induced by a tumour promoter, 12-O-tetradecanoylphorbol-13-acetate. But they did not inhibit cellular binding of phorbol-12,13-dibutylate. Lecanoric acid analogues also inhibited prostaglandin synthetase and delayed-type hypersensitivity responses against sheep red blood cells in mice. Thus, lecanoric acid analogues antagonized several enzymic and cellular effects of the tumour promoter.

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Year:  1983        PMID： 6404261     DOI： 10.1016/0006-291x(83)91022-7

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  2 in total

1.  Thapsigargin, a histamine secretagogue, is a non-12-O-tetradecanoylphorbol-13-acetate (TPA) type tumor promoter in two-stage mouse skin carcinogenesis.

Authors:  H Hakii; H Fujiki; M Suganuma; M Nakayasu; T Tahira; T Sugimura; P J Scheuer; S B Christensen
Journal:  J Cancer Res Clin Oncol       Date:  1986       Impact factor: 4.553

2.  Inhibition of tumor promotion by a lecanoric acid analogue.

Authors:  K Umezawa; T Matsushima; T Sawa; T Takeuchi; I Hirono
Journal:  Experientia       Date:  1984-01-15
  2 in total

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