Literature DB >> 6404257

Inhibition of tissue-type plasminogen activator by conditioned medium from cultured human and porcine vascular endothelial cells.

J J Emeis, V W van Hinsbergh, J H Verheijen, G Wijngaards.   

Abstract

Conditioned serum-free medium both from confluent porcine aortic endothelial cells and from human venous and arterial umbilical cord endothelial cells will inhibit plasminogen activation by tissue-type plasminogen activator. Inhibitory activity in the conditioned medium increases with time, and depends upon protein synthesis. Also, the conditioned medium directly inhibits the amidolytic activity of tissue-type plasminogen activator. Inhibitory activity can be removed from conditioned medium by absorption with immobilized tissue-type plasminogen activator.

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Year:  1983        PMID： 6404257     DOI： 10.1016/0006-291x(83)91161-0

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  17 in total

1.  Quantification of tissue-type plasminogen activator (t-PA) mRNA in human endothelial-cell cultures by hybridization with a t-PA cDNA probe.

Authors:  A J van Zonneveld; G T Chang; J van den Berg; T Kooistra; J H Verheijen; H Pannekoek; C Kluft
Journal:  Biochem J       Date:  1986-04-15       Impact factor: 3.857

2.  Cloning and sequence of a cDNA coding for the human beta-migrating endothelial-cell-type plasminogen activator inhibitor.

Authors:  T Ny; M Sawdey; D Lawrence; J L Millan; D J Loskutoff
Journal:  Proc Natl Acad Sci U S A       Date:  1986-09       Impact factor: 11.205

3.  [Significance of the endothelium of the vascular wall for maintaining hemostasis].

Authors:  U Delvos; G Müller-Berghaus
Journal:  Klin Wochenschr       Date:  1985-12-16

4.  Effect of polymyxin B and colimycin on induction of plasminogen antiactivator by lipopolysaccharide in human endothelial cell culture.

Authors:  F Dubor; A M Dosne; L A Chedid
Journal:  Infect Immun       Date:  1986-06       Impact factor: 3.441

5.  Influence of the fast-acting inhibitor of plasminogen activator on in vivo thrombolysis induced by tissue-type plasminogen activator in rabbits. Interference of tissue-derived components.

Authors:  M Colucci; J A Paramo; J M Stassen; D Collen
Journal:  J Clin Invest       Date:  1986-07       Impact factor: 14.808

6.  Activated protein C stimulates the fibrinolytic activity of cultured endothelial cells and decreases antiactivator activity.

Authors:  Y Sakata; S Curriden; D Lawrence; J H Griffin; D J Loskutoff
Journal:  Proc Natl Acad Sci U S A       Date:  1985-02       Impact factor: 11.205

Review 7.  Studies on rat mammary adenocarcinomas: a model for metastasis.

Authors:  I A Ramshaw; P Badenoch-Jones
Journal:  Cancer Metastasis Rev       Date:  1985       Impact factor: 9.264

8.  Thrombin stimulates tissue plasminogen activator release from cultured human endothelial cells.

Authors:  E G Levin; U Marzec; J Anderson; L A Harker
Journal:  J Clin Invest       Date:  1984-12       Impact factor: 14.808

9.  Generation in plasma of a fast-acting inhibitor of plasminogen activator in response to endotoxin stimulation.

Authors:  M Colucci; J A Paramo; D Collen
Journal:  J Clin Invest       Date:  1985-03       Impact factor: 14.808

10.  Two different mechanisms in patients with venous thrombosis and defective fibrinolysis: low concentration of plasminogen activator or increased concentration of plasminogen activator inhibitor.

Authors:  I M Nilsson; H Ljungnér; L Tengborn
Journal:  Br Med J (Clin Res Ed)       Date:  1985-05-18
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