New evidence for the existence of HLA-B14 subtypes. Linkage with different DR antigens.

In a joint study 109 unrelated HLA-B14 positive individuals were subtyped for the provisional splits 14.1 and 14.2 respectively, based on sera of the 7th and 8th Histocompatibility Workshops. Sixty-eight of these donors as well as 23 families were also typed for DR antigens. Earlier findings concerning a linkage disequilibrium B14.1/Aw32 and B14.2/Aw33 were confirmed. In addition a highly significant association B14.1/DR7 as well as a less striking one for B14.2/DR1 were observed. These findings contribute new arguments for the partition of the B14 antigen.