Literature DB >> 6403971

Drug signals enhance morphine tolerance development in hypophysectomized rats.

S T Tiffany, E C Petrie, E M Martin, T B Baker.   

Abstract

Hypophysectomized and sham-operated (normal) rats were given morphine (5 mg/kg) either paired or unpaired with distinctive environmental cues. Both hypophysectomized and normal animals developed analgesic tolerance when drug effects were signaled, but little tolerance was evident in either surgery group when drug was unsignaled. Results suggest that the pituitary is not critical to associational tolerance development.

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Year:  1983        PMID： 6403971     DOI： 10.1007/BF00433022

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  4 in total

1.  Evidence from rats that morphine tolerance is a learned response.

Authors:  S Siegel
Journal:  J Comp Physiol Psychol       Date:  1975-07

2.  The pituitary gland mediates acute and chronic pain responsiveness in stressed and non-stressed rats.

Authors:  S Amir; Z Amit
Journal:  Life Sci       Date:  1979-01-29       Impact factor: 5.037

3.  Endorphinergic systems and the response to stress.

Authors:  M J Millan; H M Emrich
Journal:  Psychother Psychosom       Date:  1981       Impact factor: 17.659

4.  Differential effects of hypophysectomy upon analgesia induced by two glucoprivic stressors and morphine.

Authors:  R J Bodnar; D D Kelly; A Mansour; M Glusman
Journal:  Pharmacol Biochem Behav       Date:  1979-09       Impact factor: 3.533
  4 in total
  1 in total

1.  Effect of number of conditioning trials on the development of associative tolerance to morphine.

Authors:  A Cepeda-Benito; S T Tiffany
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530
  1 in total

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