Literature DB >> 6402794

Stimulation of arachidonic acid metabolism in rat kidney mesangial cells by bradykinin, antidiuretic hormone, and their analogues.

A Uglesity, J I Kreisberg, L Levine.   

Abstract

Kinins, antidiuretic hormone, and several of their analogues stimulated contractile rat kidney mesangial cells growing in culture to produce prostaglandins E2, F2 alpha, and I2. Analogues that are known to be pharmacologically active stimulated arachidonic acid metabolism in these cells, whereas compounds that have little activity were ineffective. Stimulation of arachidonic acid metabolism by these agonists appeared to be receptor-mediated. It is possible that arachidonic acid metabolism is stimulated by contraction of mesangial cells and the released prostaglandins regulate glomerular function.

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Year:  1983        PMID： 6402794     DOI： 10.1016/s0262-1746(83)80023-7

Source DB:  PubMed          Journal:  Prostaglandins Leukot Med        ISSN： 0262-1746


  6 in total

1.  Abnormal regulation of renal kallikrein in experimental diabetes. Effects of insulin on prokallikrein synthesis and activation.

Authors:  A A Jaffa; D H Miller; G S Bailey; J Chao; H S Margolius; R K Mayfield
Journal:  J Clin Invest       Date:  1987-12       Impact factor: 14.808

2.  Converting enzyme inhibitor ramipril stimulates prostacyclin synthesis by isolated rat aorta: evidence for a kinin-dependent mechanism.

Authors:  H Scherf; R Pietsch; G Landsberg; H J Kramer; R Düsing
Journal:  Klin Wochenschr       Date:  1986-08-15

3.  Urinary kallikrein excretion in type 1 (insulin-dependent) diabetes mellitus.

Authors:  A Manto; P Cotroneo; G Porcelli; G D'Errico; G Marra; P Magnani; P Tilli; A V Greco; G Ghirlanda
Journal:  Diabetologia       Date:  1993-05       Impact factor: 10.122

4.  Renal excretion of kallikrein and eicosanoids in patients with type 1 (insulin-dependent) diabetes mellitus. Relationship to glomerular and tubular function.

Authors:  J N Harvey; A W Edmundson; A A Jaffa; L L Martin; R K Mayfield
Journal:  Diabetologia       Date:  1992-09       Impact factor: 10.122

5.  Studies on the effect of two angiotensin-converting enzyme inhibitors, captopril and cilazapril, on platelet and vascular prostaglandin metabolism in vivo.

Authors:  B Wagner; H G Eichler; B Schneider; B Blöchl-Daum; B Brenner; S Gasic; K Lechner; P A Kyrle
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-10       Impact factor: 3.000

6.  Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies.

Authors:  F J Hock; K Wirth; U Albus; W Linz; H J Gerhards; G Wiemer; S Henke; G Breipohl; W König; J Knolle
Journal:  Br J Pharmacol       Date:  1991-03       Impact factor: 8.739
  6 in total

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