Literature DB >> 6402758

Lambda Ig constant region genes are translocated to chromosome 8 in Burkitt's lymphoma with t(8;22).

A de la Chapelle, G Lenoir, J Boué, A Boué, P Gallano, C Huerre, M F Szajnert, M Jeanpierre, J M Lalouel, J C Kaplan.   

Abstract

By in situ hybridization of normal human chromosomes with a cloned genomic probe specific for the constant region of the lambda immunoglobulin genes, band 22q11 was preferentially labelled. In two cell lines with t(8;22) derived from Burkitt's lymphoma a strong signal was noted on the 8q+ chromosome derivative, indicating that the constant region of the lambda Ig gene cluster was translocated from chromosome 22 to chromosome 8. In addition, the signal observed on the 22q- derivative chromosome was stronger than the background in one of the two cell lines tested, but not in the other. The implications are that the break point in chromosome 22 in some cases lies within the Ig gene itself or between clusters of such genes, and that different cases have different break points.

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Year:  1983        PMID： 6402758      PMCID： PMC325781          DOI： 10.1093/nar/11.4.1133

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  20 in total

1.  A high resolution in situ hybridization technique for the direct visualization of labeled G-banded early metaphase and prophase chromosomes.

Authors:  M E Chandler; J J Yunis
Journal:  Cytogenet Cell Genet       Date:  1978

2.  Characteristic chromosomal abnormalities in biopsies and lymphoid-cell lines from patients with Burkitt and non-Burkitt lymphomas.

Authors:  L Zech; U Haglund; K Nilsson; G Klein
Journal:  Int J Cancer       Date:  1976-01-15       Impact factor: 7.396

3.  Translocation of immunoglobulin VH genes in Burkitt lymphoma.

Authors:  J Erikson; J Finan; P C Nowell; C M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  1982-09       Impact factor: 11.205

4.  Cytogenetic studies on African Burkitt's lymphoma cell lines: t(8;14), t(2;8) and t(8;22) translocations.

Authors:  A Bernheim; R Berger; G Lenoir
Journal:  Cancer Genet Cytogenet       Date:  1981-06

5.  Chromosomal location of the genes for human immunoglobulin heavy chains.

Authors:  C M Croce; M Shander; J Martinis; L Cicurel; G G D'Ancona; T W Dolby; H Koprowski
Journal:  Proc Natl Acad Sci U S A       Date:  1979-07       Impact factor: 11.205

6.  The isolation and characterization of linked delta- and beta-globin genes from a cloned library of human DNA.

Authors:  R M Lawn; E F Fritsch; R C Parker; G Blake; T Maniatis
Journal:  Cell       Date:  1978-12       Impact factor: 41.582

7.  A new translocation in Burkitt's tumor cells.

Authors:  R Berger; A Bernheim; H J Weh; G Flandrin; M T Daniel; J C Brouet; N Colbert
Journal:  Hum Genet       Date:  1979       Impact factor: 4.132

8.  Molecular cloning and chromosomal mapping of a human locus related to the transforming gene of Moloney murine sarcoma virus.

Authors:  K Prakash; O W McBride; D C Swan; S G Devare; S R Tronick; S A Aaronson
Journal:  Proc Natl Acad Sci U S A       Date:  1982-09       Impact factor: 11.205

9.  DNA content and DNA-based centromeric index of the 24 human chromosomes.

Authors:  M L Mendelsohn; B H Mayall; E Bogart; D H Moore; B H Perry
Journal:  Science       Date:  1973-03-16       Impact factor: 47.728

10.  2/8 translocation in a Japanese Burkitt's lymphoma.

Authors:  I Miyoshi; S Hiraki; I Kimura; K Miyamoto; J Sato
Journal:  Experientia       Date:  1979-06-15
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  17 in total

Review 1.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M R Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

2.  Delineating Rearrangements in Single Yeast Artificial Chromosomes by Quantitative DNA Fiber Mapping.

Authors:  Heinz-Ulrich G Weier; Karin M Greulich-Bode; Jenny Wu; Thomas Duell
Journal:  Open Genomics J       Date:  2009-10-09

3.  Generation of a variant t(2;8) translocation of Burkitt's lymphoma by site-specific recombination via the kappa light-chain joining signals.

Authors:  P Hartl; M Lipp
Journal:  Mol Cell Biol       Date:  1987-06       Impact factor: 4.272

4.  Chromosomal orientation of the lambda light chain locus: V lambda is proximal to C lambda in 22q11.

Authors:  B S Emanuel; L A Cannizzaro; I Magrath; Y Tsujimoto; P C Nowell; C M Croce
Journal:  Nucleic Acids Res       Date:  1985-01-25       Impact factor: 16.971

5.  The isolation of a human Ig V lambda gene from a recombinant library of chromosome 22 and estimation of its copy number.

Authors:  M L Anderson; M F Szajnert; J C Kaplan; L McColl; B D Young
Journal:  Nucleic Acids Res       Date:  1984-09-11       Impact factor: 16.971

6.  Transcriptional activation of an unrearranged and untranslocated c-myc oncogene by translocation of a C lambda locus in Burkitt.

Authors:  C M Croce; W Thierfelder; J Erikson; K Nishikura; J Finan; G M Lenoir; P C Nowell
Journal:  Proc Natl Acad Sci U S A       Date:  1983-11       Impact factor: 11.205

7.  Physical location of the human immunoglobulin lambda-like genes, 14.1, 16.1, and 16.2.

Authors:  T R Bauer; H E McDermid; M L Budarf; M L Van Keuren; B B Blomberg
Journal:  Immunogenetics       Date:  1993       Impact factor: 2.846

Review 8.  Human chromosome 22.

Authors:  J C Kaplan; A Aurias; C Julier; M Prieur; M F Szajnert
Journal:  J Med Genet       Date:  1987-02       Impact factor: 6.318

9.  Localization of the beta-globin gene by chromosomal in situ hybridization.

Authors:  C C Morton; I R Kirsch; R Taub; S H Orkin; J A Brown
Journal:  Am J Hum Genet       Date:  1984-05       Impact factor: 11.025

10.  Regional mapping of two human immunoglobulin V lambda genes and analysis of the V lambda locus in chronic myeloid leukaemia.

Authors:  M L Anderson; M H Goyns; A M Geurts van Kessel; B D Young
Journal:  Nucleic Acids Res       Date:  1985-08-26       Impact factor: 16.971
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