Literature DB >> 640271

Effect of somatostatin on basal and stimulated pancreatic secretion in the rat.

U R Fölsch, P G Lankisch, W Creutzfeldt.   

Abstract

The effect of linear somatostatin on pancreatic exocrine secretion in anaesthetized rats has been studied. Basal secretion of amylase was significantly inhibited by an infusion of 100 microgram/100 g/h somatostatin, but increased fourfold after a bolus injection of 50 microgram/100 g. CCK-stimulated enzyme and volume secretion were inhibited by somatostatin. Somatostatin did not influence secretin-stimulated bicarbonate concentration or rate of secretion in the dose range in which enzyme secretion was inhibited.

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Year:  1978        PMID： 640271     DOI： 10.1159/000198110

Source DB:  PubMed          Journal:  Digestion        ISSN： 0012-2823            Impact factor:   3.216


  8 in total

1.  Cimetidine and postprandial pancreatic exocrine secretion in dogs.

Authors:  J A Madrid; G M Salido; E Martinez de Victoria; F J Mataix
Journal:  Agents Actions       Date:  1985-12

2.  Effect of somatostatin on amylase secretion from in vivo and in vitro rat pancreas.

Authors:  M Singh
Journal:  Dig Dis Sci       Date:  1986-05       Impact factor: 3.199

3.  Metabolic manifestations of insulin deficiency do not occur without glucagon action.

Authors:  Young Lee; Eric D Berglund; May-yun Wang; Xiaorong Fu; Xinxin Yu; Maureen J Charron; Shawn C Burgess; Roger H Unger
Journal:  Proc Natl Acad Sci U S A       Date:  2012-08-13       Impact factor: 11.205

4.  Growth-hormone releasing factor does not antagonize somatostatin effects on pancreatic and gastric secretions.

Authors:  M Chovet; M Dubrasquet; J Chariot; C Rozé
Journal:  Experientia       Date:  1985-11-15

5.  Effects of long-acting somatostatin analog (SMS 201-995) on eicosanoid synthesis and survival in rats with acute necrotizing pancreatitis.

Authors:  B van Ooijen; C J Tinga; W J Kort; F J Zijlstra; S W Lamberts; J H Wilson
Journal:  Dig Dis Sci       Date:  1992-09       Impact factor: 3.199

6.  Pancreatic exocrine secretion and immunoreactive secretin release after intraduodenal instillation of 1-phenyl-1-hydroxy-n-pentane and HCl in rats.

Authors:  M Otsuki; C Sakamoto; A Ohki; H Yuu; M Maeda; S Baba
Journal:  Dig Dis Sci       Date:  1981-06       Impact factor: 3.199

7.  A small dose of somatostatin inhibits the secretin stimulated secretion of bicarbonate, amylase, and chymotrypsin in man.

Authors:  M H Vatn; E Schrumpf; K F Hanssen; J Myren
Journal:  J Endocrinol Invest       Date:  1980 Jul-Sep       Impact factor: 4.256

8.  Effects of somatostatin and pancreatic polypeptide on exocrine and endocrine pancreas in the rats.

Authors:  W Lee; K Miyazaki; A Funakoshi
Journal:  Gastroenterol Jpn       Date:  1988-02
  8 in total

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