Literature DB >> 6400032

Cyclosporine--a model for the testing of bio-immunological reaction modifiers in man.

R L Powles, B Evans, A Pedrazzini, M Crofts, P Hill, W Westensee.   

Abstract

Cyclosporine is a member of a new family of drugs which interfere and modify the biological regulation of the immune system without being cytotoxic and has now been tested extensively in man. Observation of its toxicity in a homogeneous group of 72 patients with acute myeloblastic leukaemia receiving bone marrow transplants serves to illustrate some of the new and unexpected problems that may be seen when BIRM agents start to be tested in the clinic.

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Year:  1984        PMID: 6400032     DOI: 10.1007/BF02934986

Source DB:  PubMed          Journal:  Med Oncol Tumor Pharmacother        ISSN: 0736-0118


  5 in total

1.  Cyclosporin relieves arthralgia, causes angioedema.

Authors:  D A Isenberg; M L Snaith; A A Al-Khader; S L Cohen; C Fisher; W J Morrow; J Mowbray
Journal:  N Engl J Med       Date:  1980-09-25       Impact factor: 91.245

2.  Liver disease after bone marrow transplantation.

Authors:  M J Farthing; M L Clark; J P Sloane; R L Powles; T J McElwain
Journal:  Gut       Date:  1982-06       Impact factor: 23.059

3.  Mismatched family donors for bone-marrow transplantation as treatment for acute leukaemia.

Authors:  R L Powles; G R Morgenstern; H E Kay; T J McElwain; H M Clink; P J Dady; A Barrett; B Jameson; M H Depledge; J G Watson; J Sloane; M Leigh; H Lumley; D Hedley; S D Lawler; J Filshie; B Robinson
Journal:  Lancet       Date:  1983-03-19       Impact factor: 79.321

4.  Cyclosporin A in patients receiving renal allografts from cadaver donors.

Authors:  R Y Calne; D J White; S Thiru; D B Evans; P McMaster; D C Dunn; G N Craddock; B D Pentlow; K Rolles
Journal:  Lancet       Date:  1978 Dec 23-30       Impact factor: 79.321

5.  Cyclosporin A for the treatment of graft-versus-host disease in man.

Authors:  R L Powles; A J Barrett; H Clink; H E Kay; J Sloane; T J McElwain
Journal:  Lancet       Date:  1978 Dec 23-30       Impact factor: 79.321

  5 in total

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