Literature DB >> 639860

GABA potentiates potassium-stimulated 3H-dopamine release from slices of rat substantia nigra and corpus striatum.

M S Starr.   

Abstract

GABA (10-5--10-3 M) had no effect on the spontaneous outflow of previously accumulated 3H-DA or 3H-5HT from rat nigral or striatal slices. However, GABA markedly potentiated the potassium-stimulated release of 3H-DA in both brain regions, while the depolarization-induced output of 3H-5HT was only slightly increased. This action of GABA was blocked by pictotoxin but not by bicuculline. Amphetamine likewise evoked a dose-related efflux of 3H-DA and 3H-5HT from nigra and striatum, but these releases were unchanged by GABA. The data suggest that GABA acts presynaptically in these areas to regulate dopaminergic cell function.

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Year:  1978        PMID： 639860     DOI： 10.1016/0014-2999(78)90091-2

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  13 in total

1.  Facilitation by GABA of the potassium-evoked release of 3-H-noradrenaline from the rat occipital cortex.

Authors:  S Arbilla; S Z Langer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-03       Impact factor: 3.000

Review 2.  Organization and physiology of the substantia nigra.

Authors:  H Condé
Journal:  Exp Brain Res       Date:  1992       Impact factor: 1.972

3.  Frequency-dependent, cell type-divergent signaling in the hippocamposeptal projection.

Authors:  Joanna Mattis; Julia Brill; Suzanne Evans; Talia N Lerner; Thomas J Davidson; Minsuk Hyun; Charu Ramakrishnan; Karl Deisseroth; John R Huguenard
Journal:  J Neurosci       Date:  2014-08-27       Impact factor: 6.167

4.  Diazepam facilitates the potassium-stimulated release of [3H]-dopamine from rat striatal tissue [proceedings].

Authors:  I L Martin; P R Mitchell
Journal:  Br J Pharmacol       Date:  1979-05       Impact factor: 8.739

5.  Carbon dioxide decreases the intracellular potassium activity in frog muscle [proceedings].

Authors:  F Huguenin; T Zeuthen
Journal:  J Physiol       Date:  1979-02       Impact factor: 5.182

6.  Effects of some amino acids on K+-induced release of [3H]-DA from rat striatal tissue [proceedings].

Authors:  I L Martin; P R Mitchell
Journal:  Br J Pharmacol       Date:  1980-01       Impact factor: 8.739

7.  [3H]-dopamine release from the rabbit retina.

Authors:  B Bauer; B Ehinger; L Aberg
Journal:  Albrecht Von Graefes Arch Klin Exp Ophthalmol       Date:  1980

8.  Coexistence of carriers for dopamine and GABA uptake on a same nerve terminal in the rat brain.

Authors:  G Bonanno; M Raiteri
Journal:  Br J Pharmacol       Date:  1987-05       Impact factor: 8.739

9.  GABA induced changes in acetylcholine release from slices of guinea-pig brain.

Authors:  C Bianchi; S Tanganelli; G Marzola; L Beani
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-03       Impact factor: 3.000

10.  K+-evoked release of met-enkephalin from rat striatum in vitro: effect of putative neurotransmitters and morphine.

Authors:  H Osborne; A Herz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1980-01       Impact factor: 3.000
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