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Literature DB >> 6396291

Enzymic hydrolysis of erythromycin by a strain of Escherichia coli. A new mechanism of resistance.

P Barthélémy, D Autissier, G Gerbaud, P Courvalin.

Abstract

Escherichia coli BM2195 is highly resistant to erythromycin by inactivation of the antibiotic. We have determined the structure of the modified antibiotic by physico-chemical techniques including mass spectrometry, infrared spectrophotometry, 13C nuclear magnetic resonance, and circular dichroism. The results obtained indicate that E. coli BM2195 resists erythromycin by the production of an erythromycin esterase which hydrolyzes the lactone ring of the antibiotic.

Entities: Chemical Species

Mesh：

Substances：
Erythromycin

Year: 1984 PMID： 6396291 DOI： 10.7164/antibiotics.37.1692

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

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Cited

30 in total

1. Decreased azithromycin susceptibility of Neisseria gonorrhoeae due to mtrR mutations.

Authors: L Zarantonelli; G Borthagaray; E H Lee; W M Shafer
Journal: Antimicrob Agents Chemother Date: 1999-10 Impact factor: 5.191

Review 2. Intrinsic and unusual resistance to macrolide, lincosamide, and streptogramin antibiotics in bacteria.

Authors: R Leclercq; P Courvalin
Journal: Antimicrob Agents Chemother Date: 1991-07 Impact factor: 5.191

3. Application of nanoscale packed capillary liquid chromatography (75 μm id) and capillary zone electrophoresis/electrospray ionization mass spectrometry to the analysis of macrolide antibiotics.

Authors: C E Parker; J R Perkins; K B Tomer; Y Shida; K O'Hara; M Kono
Journal: J Am Soc Mass Spectrom Date: 1992-07 Impact factor: 3.109

4. Increased kasugamycin sensitivity in Escherichia coli caused by the presence of an inducible erythromycin resistance (erm) gene of Streptococcus pyogenes.

Authors: A N Suvorov; B van Gemen; P H van Knippenberg
Journal: Mol Gen Genet Date: 1988-12

10. Molecular mechanisms of anti-inflammatory action of erythromycin in human bronchial epithelial cells: possible role in the signaling pathway that regulates nuclear factor-kappaB activation.

Authors: Masashi Desaki; Hitoshi Okazaki; Toshiaki Sunazuka; Satoshi Omura; Kazuhiko Yamamoto; Hajime Takizawa
Journal: Antimicrob Agents Chemother Date: 2004-05 Impact factor: 5.191

Enzymic hydrolysis of erythromycin by a strain of Escherichia coli. A new mechanism of resistance.

1. Decreased azithromycin susceptibility of Neisseria gonorrhoeae due to mtrR mutations.

Review 2. Intrinsic and unusual resistance to macrolide, lincosamide, and streptogramin antibiotics in bacteria.

3. Application of nanoscale packed capillary liquid chromatography (75 μm id) and capillary zone electrophoresis/electrospray ionization mass spectrometry to the analysis of macrolide antibiotics.

4. Increased kasugamycin sensitivity in Escherichia coli caused by the presence of an inducible erythromycin resistance (erm) gene of Streptococcus pyogenes.

Review 5. The macrolide antibiotic renaissance.

6. Plasmid-mediated susceptibility to intestinal microbial antagonisms in Escherichia coli.

Review 7. Resistance to Macrolide Antibiotics in Public Health Pathogens.

8. Clinical strain of Staphylococcus aureus inactivates and causes efflux of macrolides.

9. Analysis of the nucleotide sequence of the ereB gene encoding the erythromycin esterase type II.

10. Molecular mechanisms of anti-inflammatory action of erythromycin in human bronchial epithelial cells: possible role in the signaling pathway that regulates nuclear factor-kappaB activation.