Literature DB >> 6396084

The myc proteins are not associated with chromatin in mitotic cells.

R Winqvist, K Saksela, K Alitalo.   

Abstract

The protein products of cellular and viral myc oncogenes are detected in nuclei by immunofluorescence. No myc fluorescence is found in nucleoli. In mitotic cells the myc antigens are not found associated with metaphase chromosomes, but are diffusely distributed throughout the cytoplasm. Cytoplasmic myc fluorescence is first observed when chromatin begins to condense in early prophase. Granular nuclear myc fluorescence is again discerned in telophase cells, when the nuclear envelope is formed and becomes more prominent upon cytokinesis; concomitantly the diffuse cytoplasmic myc staining is lost. These results suggest that myc proteins not only bind to DNA or chromatin, but are also associated with other structural systems in the nuclei.

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Year:  1984        PMID： 6396084      PMCID： PMC557794          DOI： 10.1002/j.1460-2075.1984.tb02237.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  39 in total

1.  Bacterial expression of an enzymatically active protein encoded by RSV src gene.

Authors:  J P McGrath; A D Levinson
Journal:  Nature       Date:  1982-02-04       Impact factor: 49.962

2.  Nuclear localization and DNA binding of the transforming gene product of avian myelocytomatosis virus.

Authors:  P Donner; I Greiser-Wilke; K Moelling
Journal:  Nature       Date:  1982-03-18       Impact factor: 49.962

3.  Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas.

Authors:  G S Payne; J M Bishop; H E Varmus
Journal:  Nature       Date:  1982-01-21       Impact factor: 49.962

Review 4.  Specific chromosomal translocations and the genesis of B-cell-derived tumors in mice and men.

Authors:  G Klein
Journal:  Cell       Date:  1983-02       Impact factor: 41.582

5.  Nucleotide sequence to the v-myc oncogene of avian retrovirus MC29.

Authors:  K Alitalo; J M Bishop; D H Smith; E Y Chen; W W Colby; A D Levinson
Journal:  Proc Natl Acad Sci U S A       Date:  1983-01       Impact factor: 11.205

6.  Nuclear lamina and the structural organization of the nuclear envelope.

Authors:  L Gerace; G Blobel
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1982

7.  Nuclear location of the putative transforming protein of avian myelocytomatosis virus.

Authors:  H D Abrams; L R Rohrschneider; R N Eisenman
Journal:  Cell       Date:  1982-06       Impact factor: 41.582

8.  Subgenomic mRNA in OK10 defective leukemia virus-transformed cells.

Authors:  S Saule; A Sergeant; G Torpier; M B Raes; S Pfeifer; D Stehelin
Journal:  J Virol       Date:  1982-04       Impact factor: 5.103

9.  Identification of human adenovirus early region 1 products by using antisera against synthetic peptides corresponding to the predicted carboxy termini.

Authors:  S P Yee; D T Rowe; M L Tremblay; M McDermott; P E Branton
Journal:  J Virol       Date:  1983-06       Impact factor: 5.103

10.  Decreased DNA-binding ability of purified transformation-specific proteins from deletion mutants of the acute avian leukemia virus MC29.

Authors:  P Donner; T Bunte; I Greiser-Wilke; K Moelling
Journal:  Proc Natl Acad Sci U S A       Date:  1983-05       Impact factor: 11.205
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  11 in total

1.  Localization in situ of c-myc mRNA and c-myc protein in adult mouse testis.

Authors:  T Koji; S Izumi; M Tanno; T Moriuchi; P K Nakane
Journal:  Histochem J       Date:  1988-10

2.  Functional role of newly formed pore complexes in postmitotic nuclear reorganization.

Authors:  R Benavente; M C Dabauvalle; U Scheer; N Chaly
Journal:  Chromosoma       Date:  1989-10       Impact factor: 4.316

3.  Multiple growth-associated nuclear proteins immunoprecipitated by antisera raised against human c-myc peptide antigens.

Authors:  H Persson; H E Gray; F Godeau; S Braunhut; A R Bellvé
Journal:  Mol Cell Biol       Date:  1986-03       Impact factor: 4.272

4.  c-myc protein in normal tissue. Effects of fixation on its apparent subcellular distribution.

Authors:  S L Loke; L M Neckers; G Schwab; E S Jaffe
Journal:  Am J Pathol       Date:  1988-04       Impact factor: 4.307

5.  Nuclear colocalization of cellular and viral myc proteins with HSP70 in myc-overexpressing cells.

Authors:  P J Koskinen; L Sistonen; G Evan; R Morimoto; K Alitalo
Journal:  J Virol       Date:  1991-02       Impact factor: 5.103

6.  Rapid phosphorylation of the L-myc protein induced by phorbol ester tumor promoters and serum.

Authors:  K Saksela; T P Mäkelä; G Evan; K Alitalo
Journal:  EMBO J       Date:  1989-01       Impact factor: 11.598

7.  Mitotic bookmarking by transcription factors.

Authors:  Stephan Kadauke; Gerd A Blobel
Journal:  Epigenetics Chromatin       Date:  2013-04-02       Impact factor: 4.954

Review 8.  Protein phosphatases at the nuclear envelope.

Authors:  Raquel Sales Gil; Ines J de Castro; Jerusalem Berihun; Paola Vagnarelli
Journal:  Biochem Soc Trans       Date:  2018-02-06       Impact factor: 5.407

9.  Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation.

Authors:  Kevin Myant; Xi Qiao; Tuuli Halonen; Christophe Come; Anni Laine; Mahnaz Janghorban; Johanna I Partanen; John Cassidy; Erinn-Lee Ogg; Patrizia Cammareri; Tiina Laiterä; Juha Okkeri; Juha Klefström; Rosalie C Sears; Owen J Sansom; Jukka Westermarck
Journal:  Cell Rep       Date:  2015-07-30       Impact factor: 9.423

10.  Mitosis-specific phosphorylation of the nuclear oncoproteins Myc and Myb.

Authors:  B Lüscher; R N Eisenman
Journal:  J Cell Biol       Date:  1992-08       Impact factor: 10.539
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