| Literature DB >> 6395826 |
A Danysz, K Wierzba, M Wutkiewicz, A Pniewska, T Pragłowski, I Burba-Anczewska.
Abstract
The influence of three chosen model sulfhydryl groups containing compounds, characterized by increasing size of molecule--cysteine, glutathione and insulin on antineoplastic activity of 5-fluorouracil (5-FU) and 6-mercaptopurine (6-MP) against murine leukemia L-1210 5-FU and 6-MP and murine sarcoma Sa 180, was studied. Sulfhydryl compounds failed to change in most cases the therapeutic (antineoplastic) effect of 5-FU and 6-MP. However, certain doses of these sulfhydryl compounds enhanced the cytostatic effect of 6-MP in respect to Sa-180.Entities:
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Year: 1984 PMID： 6395826
Source DB: PubMed Journal: Arch Immunol Ther Exp (Warsz) ISSN： 0004-069X Impact factor: 4.291