Literature DB >> 6393953

Effect of insulin on glucose metabolism in adipocytes from virgin and late-pregnant rats.

A Leturque, M Guerre-Millo, M Lavau, J Girard.   

Abstract

Under basal conditions (zero insulin), paraovarian adipocytes from 19-day-pregnant rats exhibited the same rates of [U-14C]glucose conversion into CO2 and total lipids as did those from age-matched virgin rats. The dose-response curves for insulin stimulation of glucose metabolism were similar in both groups: maximal response (+100% over basal values) and high sensitivity (half-maximal effect at 0.05 nM-insulin). The present results suggest that the insulin resistance in vivo that occurs during late pregnancy may involve circulating factors lost in vitro.

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Year:  1984        PMID： 6393953      PMCID： PMC1144483          DOI： 10.1042/bj2240685

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  28 in total

Review 1.  Carbohydrate and lipid metabolism during normal pregnancy: relationship to gestational hormone action.

Authors:  R K Kalkhoff; A H Kissebah; H J Kim
Journal:  Semin Perinatol       Date:  1978-10       Impact factor: 3.300

2.  Microdetermination of long-chain fatty acids in plasma and tissues.

Authors:  V P DOLE; H MEINERTZ
Journal:  J Biol Chem       Date:  1960-09       Impact factor: 5.157

3.  A reliable photomicrographic method to determining fat cell size and number: application to dietary obesity.

Authors:  M Lavau; C Susini; J Knittle; S Blanchet-Hirst; M R Greenwood
Journal:  Proc Soc Exp Biol Med       Date:  1977-11

4.  Serum progesterone and immuno-reactive insulin levels in the pregnant rat.

Authors:  M T Sutter-Dub; R Leclercq; J M Felix; R Jacquot; B C Sutter
Journal:  Horm Metab Res       Date:  1973-01       Impact factor: 2.936

5.  2 phases of adipose tissue metabolism in pregnancy: maternal adaptations for fetal growth.

Authors:  R H Knopp; C D Saudek; R A Arky; J B O'Sullivan
Journal:  Endocrinology       Date:  1973-04       Impact factor: 4.736

6.  Carbohydrate metabolism in pregnancy. VII. Insulin tolerance during late pregnancy in the fed and fasted rat.

Authors:  R H Knopp; H J Ruder; E Herrera; N Freinkel
Journal:  Acta Endocrinol (Copenh)       Date:  1970-10

7.  Effect of HPL and pregnancy on glucose uptake in rat adipose tissue.

Authors:  N H Leake; R L Burt
Journal:  Am J Obstet Gynecol       Date:  1969-01-01       Impact factor: 8.661

8.  Radioreceptor assay for prolactin and other lactogenic hormones.

Authors:  R P Shiu; P A Kelly; H G Friesen
Journal:  Science       Date:  1973-06-01       Impact factor: 47.728

9.  Mechanism of insulin resistance in adipocytes of rats fed a high-fat diet.

Authors:  M Lavau; S K Fried; C Susini; P Freychet
Journal:  J Lipid Res       Date:  1979-01       Impact factor: 5.922

10.  Relative effects of pregnancy, estradiol, and progesterone on plasma insulin and pancreatic islet insulin secretion.

Authors:  N V Costrini; R K Kalkhoff
Journal:  J Clin Invest       Date:  1971-05       Impact factor: 14.808
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  2 in total

1.  Changes in activity and intra-acinar distribution of glucose-6-phosphate dehydrogenase and malic enzyme during pregnancy in rat liver.

Authors:  A P Newham; K Krieger; I P Maly; D Sasse
Journal:  Histochemistry       Date:  1991

2.  Tyrosine kinase activity of liver insulin receptor is inhibited in rats at term gestation.

Authors:  C Martínez; P Ruiz; A Andrés; J Satrústegui; J M Carrascosa
Journal:  Biochem J       Date:  1989-10-01       Impact factor: 3.857
  2 in total

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