The quantitative structure-activity relationship approach to the mutagenicity of N-nitrosomethylaniline compounds.

In order to clarify the correlations between the substituent properties and the mutagenicity of N-nitrosomethylaniline compounds, the quantitative structure-activity relationship approach has been applied. The results indicate that the property and the shape of the para-substituent groups influence the mutagenic potency, although this has not yet been verified for the meta-substituted compounds.