Literature DB >> 6391951

The role of phosphoenolpyruvate in insulin secretion: the effect of L-phenylalanine.

T A Chatterton, C H Reynolds, N R Lazarus, C I Pogson.   

Abstract

Incubation of rat islets with phenylalanine increased the tissue content of phosophoenolpyruvate, both in the presence and in the absence of glucose. At the same time, L-phenylalanine neither stimulated nor inhibited insulin release. It is unlikely that insulin secretion is tightly coupled to the availability of phosphoenolpyruvate in rat islets.

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Year:  1984        PMID: 6391951     DOI: 10.1007/BF01951926

Source DB:  PubMed          Journal:  Experientia        ISSN: 0014-4754


  29 in total

1.  Immunoassay of insulin with insulin-antibody precipitate.

Authors:  C N HALES; P J RANDLE
Journal:  Biochem J       Date:  1963-07       Impact factor: 3.857

2.  Regulation of 3',5'-cyclic AMP-dependent protein kinase in the plasma membrane of cod (Gadus callarius) and mouse islets.

Authors:  B DPAVIS; N R Lazarus
Journal:  J Membr Biol       Date:  1975       Impact factor: 1.843

Review 3.  Some special kinetic problems of transport.

Authors:  H N Christensen
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  1969

4.  A sensitive and specific assay for GTP and GDP in tissue extracts.

Authors:  C I Pogson; S V Gurnah; S A Smith
Journal:  Int J Biochem       Date:  1979

5.  The stimulus-secretion coupling of amino acid-induced insulin release. Biosynthetic and secretory responses of rat pancreatic islet to L-leucine and L-glutamine.

Authors:  A Sener; G Somers; G Devis; W J Malaisse
Journal:  Diabetologia       Date:  1981-08       Impact factor: 10.122

6.  The effect of phosphoenolpyruvate on the retention of calcium by liver mitochondria.

Authors:  I Roos; M Crompton; E Carafoli
Journal:  FEBS Lett       Date:  1978-10-15       Impact factor: 4.124

7.  Effects of glucose, glucose metabolites and calcium ions on adenylate cyclase activity in homogenates of mouse pancreatic islets.

Authors:  K Capito; C J Hedeskov
Journal:  Biochem J       Date:  1977-03-15       Impact factor: 3.857

8.  The stimulus-secretion coupling of glucose-induced insulin release. Metabolism of glucose in K+-deprived islets.

Authors:  A Sener; S Kawazu; W J Malaisse
Journal:  Biochem J       Date:  1980-01-15       Impact factor: 3.857

9.  Phosphoenolpyruvate in rat pancreatic islets: a possible intracellular trigger of insulin release?

Authors:  M C Sugden; S J Ashcroft
Journal:  Diabetologia       Date:  1977-09       Impact factor: 10.122

10.  Mechanism of 3-phenylpyruvate-induced insulin release. Metabolic aspects.

Authors:  W J Malaisse; A Sener; M Welsh; F Malaisse-Lagae; C Hellerström; J Christophe
Journal:  Biochem J       Date:  1983-03-15       Impact factor: 3.857

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  2 in total

1.  Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion.

Authors:  Romana Stark; Francisco Pasquel; Adina Turcu; Rebecca L Pongratz; Michael Roden; Gary W Cline; Gerald I Shulman; Richard G Kibbey
Journal:  J Biol Chem       Date:  2009-07-27       Impact factor: 5.157

2.  Ingestion of leucine + phenylalanine with glucose produces an additive effect on serum insulin but less than additive effect on plasma glucose.

Authors:  Jennifer F Iverson; Mary C Gannon; Frank Q Nuttall
Journal:  J Amino Acids       Date:  2013-07-29
  2 in total

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