Literature DB >> 6391659

Effect of cis-platinum on human blood monocyte function in vitro.

H Nielsen.   

Abstract

The influence of cis-diamminedichloroplatinum(II) (cis-DDP) on human blood monocyte functions in vitro was studied. With cis-DDP added to the cell suspensions in concentrations between 10(2) and 10(-6) microM just before assay of monocyte functional capacity no significant changes in chemotactic, chemokinetic, phagocytic, or fungicidal activities were observed. However, with preincubation at 1 microM for 60 min cis-DDP selectively inhibited chemotaxis, but not chemokinesis or phagocytosis. This inhibition was more pronounced at 37 degrees C than at 4 degrees C, and was not reversed by washing of the cells. The implications of these findings for clinical oncology are discussed.

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Year:  1984        PMID： 6391659     DOI： 10.1007/BF00205515

Source DB:  PubMed          Journal:  Cancer Immunol Immunother        ISSN： 0340-7004            Impact factor:   6.968


  18 in total

Review 1.  Mechanism of action of cis-dichlorodiammineplatinum(II).

Authors:  L A Zwelling; K W Kohn
Journal:  Cancer Treat Rep       Date:  1979 Sep-Oct

2.  Discrimination between neoplastic and non-neoplastic cells in vitro by activated macrophages.

Authors:  J B Hibbs
Journal:  J Natl Cancer Inst       Date:  1974-11       Impact factor: 13.506

3.  Binding of an antitumor platinum compound to cells as influenced by physical factors and pharmacologically active agents.

Authors:  G R Gale; C R Morris; L M Atkins; A B Smith
Journal:  Cancer Res       Date:  1973-04       Impact factor: 12.701

4.  Cis-dichlorodiammineplatinum [II]: inhibition of nucleic acid synthesis in lymphocytes stimulated with phytohemagglutinin.

Authors:  J A Howle; H S Thompson; A E Stone; G R Gale
Journal:  Proc Soc Exp Biol Med       Date:  1971-07

5.  Immunosuppression with cis-platinum (II) diamminodichloride: effect on antibody plaque-forming spleen cells.

Authors:  A Khan; J M Hill
Journal:  Infect Immun       Date:  1971-09       Impact factor: 3.441

6.  Differential chemotherapeutic susceptibility of human T-lymphocytes and B-lymphocytes in culture.

Authors:  T Ohnuma; H Arkin; J Minowada; J F Holland
Journal:  J Natl Cancer Inst       Date:  1978-04       Impact factor: 13.506

7.  Human monocyte chemotaxis in vitro. Influence of in vitro variables in the filter assay.

Authors:  H Nielsen; S Olesen Larsen
Journal:  Acta Pathol Microbiol Immunol Scand C       Date:  1983-04

8.  Plasma levels and urinary excretion of filterable platinum species following bolus injection and iv infusion of cis-dichlorodiammineplatinum(II) in man.

Authors:  T F Patton; K J Himmelstein; R Belt; S J Bannister; L A Sternson; A J Repta
Journal:  Cancer Treat Rep       Date:  1978-09

9.  Biological activity of metal complexes. V: Influence of Pd(II), Pt(II), and Rh(I) on the macrophages chemotaxis.

Authors:  M Aresta; M De Fazio; R Fumarulo; D Giordano; R Pantaleo; S Riccardi
Journal:  Biochem Biophys Res Commun       Date:  1982-01-15       Impact factor: 3.575

10.  Monocyte function in man.

Authors:  M C Territo; M J Cline
Journal:  J Immunol       Date:  1977-01       Impact factor: 5.422
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  3 in total

1.  Mononuclear phagocyte system function and nanoparticle pharmacology in obese and normal weight ovarian and endometrial cancer patients.

Authors:  Brittney R Starling; Parag Kumar; Andrew T Lucas; David Barrow; Laura Farnan; Laura Hendrix; Hugh Giovinazzo; Gina Song; Paola Gehrig; Jeannette T Bensen; William C Zamboni
Journal:  Cancer Chemother Pharmacol       Date:  2018-10-16       Impact factor: 3.333

2.  Translational studies of phenotypic probes for the mononuclear phagocyte system and liposomal pharmacology.

Authors:  Whitney P Caron; John C Lay; Alan M Fong; Ninh M La-Beck; Parag Kumar; Suzanne E Newman; Haibo Zhou; Jane H Monaco; Daniel L Clarke-Pearson; Wendy R Brewster; Linda Van Le; Victoria L Bae-Jump; Paola A Gehrig; William C Zamboni
Journal:  J Pharmacol Exp Ther       Date:  2013-09-16       Impact factor: 4.030

3.  Murine tissues exposed to cytotoxic drugs display altered patterns of Candida albicans adhesion.

Authors:  J L López-Ribot; C S McVay; W L Chaffin
Journal:  Infect Immun       Date:  1994-10       Impact factor: 3.441
  3 in total

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