Cervical carcinoma in situ associated with azathioprine therapy. A case report and literature review.

The case of a 34-year-old kidney transplant patient who developed carcinoma in situ of the cervix after immunosuppressive therapy with azathioprine is reported. A few case reports and studies of this association have appeared previously in the literature, in addition to many reports associating azathioprine treatment with other malignant tumors. This report reemphasizes this association and the need for close surveillance of patients undergoing immunosuppressive therapy. The pertinent literature on the association of chronic use of immunosuppressive agents with the subsequent development of malignant tumors is briefly reviewed.