Literature DB >> 6390680

Essential role of insulin in transcription of the rat 25,000 molecular weight casein gene.

P Chomczynski, P Qasba, Y J Topper.   

Abstract

Insulin is essential for the accumulation of rat casein messenger RNA (mRNA) in the presence of glucocorticoid and prolactin. The accumulation of certain mRNA's in other tissues has also been linked to insulin action. The present study shows that the accumulation effect on the 25,000 molecular weight rat casein mRNA does not reflect stabilization of the transcript by insulin. Rather, insulin is essential for its synthesis in the presence of glucocorticoid and prolactin.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6390680     DOI： 10.1126/science.6390680

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  12 in total

Review 1.  IGF and insulin action in the mammary gland: lessons from transgenic and knockout models.

Authors:  D L Hadsell; S G Bonnette
Journal:  J Mammary Gland Biol Neoplasia       Date:  2000-01       Impact factor: 2.673

Review 2.  Translational regulation of milk protein synthesis at secretory activation.

Authors:  Robert E Rhoads; Ewa Grudzien-Nogalska
Journal:  J Mammary Gland Biol Neoplasia       Date:  2007-11-17       Impact factor: 2.673

Review 3.  Regulation of gene expression by insulin.

Authors:  R M O'Brien; D K Granner
Journal:  Biochem J       Date:  1991-09-15       Impact factor: 3.857

4.  Insulin and prolactin synergize to induce translation of human serum albumin in the mammary gland of transgenic mice.

Authors:  A Baruch; M Shani; I Barash
Journal:  Transgenic Res       Date:  1998-01       Impact factor: 2.788

5.  Both cell substratum regulation and hormonal regulation of milk protein gene expression are exerted primarily at the posttranscriptional level.

Authors:  R S Eisenstein; J M Rosen
Journal:  Mol Cell Biol       Date:  1988-08       Impact factor: 4.272

6.  Linoleic acid, but not cortisol, stimulates accumulation of casein by mouse mammary epithelial cells in serum-free collagen gel culture.

Authors:  B K Levay-Young; G K Bandyopadhyay; S Nandi
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

7.  Insulin, a key regulator of hormone responsive milk protein synthesis during lactogenesis in murine mammary explants.

Authors:  Karensa K Menzies; Heather J Lee; Christophe Lefèvre; Christopher J Ormandy; Keith L Macmillan; Kevin R Nicholas
Journal:  Funct Integr Genomics       Date:  2009-10-15       Impact factor: 3.410

8.  Insulin and insulin-like growth factor I exert different effects on plasminogen activator production or cell growth in the ovine thyroid cell line OVNIS.

Authors:  B Degryse; F Maisonobe; S Hovsépian; G Fayet
Journal:  J Endocrinol Invest       Date:  1991-11       Impact factor: 4.256

9.  Hepatic nuclear factor 3- and hormone-regulated expression of the phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein 1 genes.

Authors:  R M O'Brien; E L Noisin; A Suwanichkul; T Yamasaki; P C Lucas; J C Wang; D R Powell; D K Granner
Journal:  Mol Cell Biol       Date:  1995-03       Impact factor: 4.272

10.  Synthesis and secretion of human serum albumin by mammary gland explants of virgin and lactating transgenic mice.

Authors:  I Barash; A Faerman; A Baruch; M Nathan; D R Hurwitz; M Shani
Journal:  Transgenic Res       Date:  1993-09       Impact factor: 2.788
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.