Literature DB >> 6390058

In vivo inhibition of liver alcohol dehydrogenase by ethanol administration.

M Sharkawi.   

Abstract

The activity of liver alcohol dehydrogenase (LADH) from rats sacrificed two hours after the administration of ethanol 3, 4 or 5 g/kg intraperitoneally was significantly inhibited compared to the activity of LADH from control rats. LADH activity was inversely related to the dose of ethanol administered, to the concentration of ethanol in the liver, and to the concentration of ethanol in the blood. The clearance of blood ethanol in rats was dose-dependent and was inversely related to the dose administered. The half-life of ethanol elimination increased as the dose of ethanol increased. These results suggest that ethanol-induced inhibition of LADH can occur in vivo and that the level of activity of this enzyme determines the rate of oxidation of ethanol.

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Year:  1984        PMID： 6390058     DOI： 10.1016/0024-3205(84)90527-7

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  12 in total

1.  Pancreatic injury in hepatic alcohol dehydrogenase-deficient deer mice after subchronic exposure to ethanol.

Authors:  Bhupendra S Kaphalia; Kamlesh K Bhopale; Shakuntala Kondraganti; Hai Wu; Paul J Boor; G A Shakeel Ansari
Journal:  Toxicol Appl Pharmacol       Date:  2010-05-15       Impact factor: 4.219

2.  Proteins Differentially Expressed in the Pancreas of Hepatic Alcohol Dehydrogenase-Deficient Deer Mice Fed Ethanol For 3 Months.

Authors:  Kamlesh K Bhopale; Samir M Amer; Lata Kaphalia; Kizhake V Soman; John E Wiktorowicz; Ghulam A Shakeel Ansari; Bhupendra S Kaphalia
Journal:  Pancreas       Date:  2017-07       Impact factor: 3.327

3.  Proteomic Profiling of Liver and Plasma in Chronic Ethanol Feeding Model of Hepatic Alcohol Dehydrogenase-Deficient Deer Mice.

Authors:  Kamlesh K Bhopale; Samir M Amer; Lata Kaphalia; Kizhake V Soman; John E Wiktorowicz; Ghulam A Shakeel Ansari; Bhupendra S Kaphalia
Journal:  Alcohol Clin Exp Res       Date:  2017-09-08       Impact factor: 3.455

4.  Exposure to binge ethanol and fatty acid ethyl esters exacerbates chronic ethanol-induced pancreatic injury in hepatic alcohol dehydrogenase-deficient deer mice.

Authors:  Mukund P Srinivasan; Kamlesh K Bhopale; Anna A Caracheo; Lata Kaphalia; Bin Gong; Vsevolod L Popov; Paul J Boor; G A Shakeel Ansari; Bhupendra S Kaphalia
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2022-01-05       Impact factor: 4.052

Review 5.  A new view of alcohol metabolism and alcoholism--role of the high-Km Class III alcohol dehydrogenase (ADH3).

Authors:  Takeshi Haseba; Youkichi Ohno
Journal:  Int J Environ Res Public Health       Date:  2010-03-15       Impact factor: 3.390

6.  Hepatic lipid profiling of deer mice fed ethanol using ¹H and ³¹P NMR spectroscopy: a dose-dependent subchronic study.

Authors:  Harshica Fernando; Kamlesh K Bhopale; Paul J Boor; G A Shakeel Ansari; Bhupendra S Kaphalia
Journal:  Toxicol Appl Pharmacol       Date:  2012-08-03       Impact factor: 4.219

7.  Identification of arsenite-and arsenic diglutathione-binding proteins in human hepatocarcinoma cells.

Authors:  Ayano Mizumura; Takayuki Watanabe; Yayoi Kobayashi; Seishiro Hirano
Journal:  Toxicol Appl Pharmacol       Date:  2009-10-27       Impact factor: 4.219

8.  Hepatic alcohol dehydrogenase deficiency induces pancreatic injury in chronic ethanol feeding model of deer mice.

Authors:  Samir M Amer; Kamlesh K Bhopale; Ramu D Kakumanu; Vsevolod L Popov; Bill A Rampy; Inas H El-Mehallawi; Magdy M Ashmawy; G A Shakeel Ansari; Bhupendra S Kaphalia
Journal:  Exp Mol Pathol       Date:  2018-01-11       Impact factor: 3.362

9.  Hepatic alcohol dehydrogenase activity in alcoholic subjects with and without liver disease.

Authors:  F Vidal; J Perez; J Morancho; B Pinto; C Richart
Journal:  Gut       Date:  1990-06       Impact factor: 23.059

10.  Differential cytotoxicity, ER/oxidative stress, dysregulated AMPKα signaling, and mitochondrial stress by ethanol and its metabolites in human pancreatic acinar cells.

Authors:  Mukund P Srinivasan; Kamlesh K Bhopale; Anna A Caracheo; Lata Kaphalia; Gopalakrishnan Loganathan; Appakalai N Balamurugan; Cristiana Rastellini; Bhupendra S Kaphalia
Journal:  Alcohol Clin Exp Res       Date:  2021-04-02       Impact factor: 3.455
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