Computed tomography findings in 15 cases of Creutzfeldt-Jakob disease with histological verification.

Computed tomography (CT) was normal in twelve of fifteen patients with definite Creutzfeldt-Jakob disease. In two patients CT showed mild sulcal widening, while marked ventricular enlargement and moderate cortical atrophy were seen in a patient who had both Creutzfeldt-Jakob disease and normal pressure hydrocephalus. No correspondence was observed between CT findings, severity of the clinical picture and postmorten gross brain examination. According to these results, a normal CT in a demented patient should suggest Creutzfeldt-Jakob disease. Conversely, CT is of value for the diagnosis of other potentially reversible illnesses clinically resembling Creutzfeldt-Jakob disease.